Lipid nanoparticles for nucleic acid delivery: Current perspectives.

Advanced Drug Delivery Reviews
Eleni SamaridouPeter Lutwyche

Abstract

Nucleic Acid (NA) based therapeutics are poised to disrupt modern medicine and augment traditional pharmaceutics in a meaningful way. However, a key challenge to advancing NA therapies into the clinical setting and on to the market is the safe and effective delivery to the target tissue and cell. Lipid Nanoparticles (LNP) have been extensively investigated and are currently the most advanced vector for the delivery of NA drugs, as evidenced by the approval of Onpattro for treatment of Amyloidosis in the US and EU in 2018. This article provides a comprehensive review of the state-of-the-art for LNP technology. We discuss key advances in the design and development of LNP, leading to a broad range of therapeutic applications. Finally, the current status of this technology in clinical trials and its future prospects are discussed.

Citations

Sep 5, 2020·Pharmaceutics·Shi Su, Peter M Kang
Jan 6, 2021·Advanced Drug Delivery Reviews·Jeonghwan KimGaurav Sahay
Feb 6, 2021·Pharmaceutics·Basmah N AldosariAlanood S Almurshedi
Feb 18, 2021·Molecular Cancer·Yang WangXiawei Wei
Feb 23, 2021·Molecular Therapy. Methods & Clinical Development·Mitchel J R RuigrokWouter L J Hinrichs
Mar 26, 2021·Molecular Cancer·Tina BriolayNicolas Boisgerault
Apr 4, 2021·Cancers·Olivia A Diaz Arguello, Hidde J Haisma
Apr 1, 2021·Bioengineering & Translational Medicine·Michele SchlichPaolo Decuzzi
Apr 28, 2021·Current Opinion in Virology·Botond Z IgyártóSonia Ndeupen
Apr 13, 2021·Advanced Drug Delivery Reviews·Dongmei CunMingshi Yang
Jun 3, 2021·Pharmaceutics·Ammar S Al Khafaji, Maureen D Donovan
May 22, 2021·Advanced Drug Delivery Reviews·Zehua LiuHélder A Santos
Jun 20, 2021·Small·Xin FuXiaoli Zhu
Jul 5, 2021·International Journal of Pharmaceutics·Manon BergerGéraldine Piel
Jul 16, 2021·Molecular Pharmaceutics·Despo ChatzikleanthousRoberto Adamo
Aug 6, 2021·Biomedical Engineering Letters·Victor Aaron SiosonJinmyoung Joo
Aug 2, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Adriana TrapaniMassimo Conese
Jun 30, 2021·Expert Review of Vaccines·Christopher P Karch, Gary R Matyas
Jul 27, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bianca N Valdés-FernándezGualberto Ruaño
Aug 18, 2021·Pharmacology & Therapeutics·Ai-Ming Yu, Mei-Juan Tu
Aug 29, 2021·Pharmaceutics·Erica QuagliariniGiulio Caracciolo
Sep 1, 2021·Journal of Industrial Microbiology & Biotechnology·Evelyn C Mollocana-LaraFernando A Gonzales-Zubiate
Dec 22, 2021·Molecular Pharmaceutics·Joachim Justad RøiseNiren Murthy
Dec 8, 2021·Nanotechnology·Eberechukwu Victoria AmadiChris Papadopoulos
Jan 26, 2022·Journal of Biomedical Materials Research. Part a·Hanwen ZhangMichael J Mitchell

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