Lipid pathway deregulation in advanced prostate cancer

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Laura GalbraithImran Ahmad

Abstract

The link between prostate cancer (PC) development and lipid metabolism is well established, with AR intimately involved in a number of lipogenic processes involving SREBP1, PPARG, FASN, ACC, ACLY and SCD1. Recently, there is growing evidence implicating the role of obesity and peri-prostatic adipose tissue (PPAT) in PC aggressiveness and related mortality, suggesting the importance of lipid pathways in both localised and disseminated disease. A number of promising agents are in development to target the lipogenic axis in PC, and the likelihood is that these agents will form part of combination drug strategies, with targeting of multiple metabolic pathways (e.g. FASN and CPT1), or in combination with AR pathway inhibitors (SCD1 and AR).

Citations

Jun 6, 2018·Current Osteoporosis Reports·Jonathan D DiedrichIzabela Podgorski
Mar 27, 2019·Scientific Reports·Alberto Sola-LeyvaMaría P Carrasco-Jiménez
Feb 6, 2020·International Journal of Molecular Sciences·Raffaele ConteAnna Calarco
Aug 10, 2019·Molecular Cancer Therapeutics·Krishna B SinghShivendra V Singh
Feb 19, 2019·Asian Journal of Urology·Lingfan XuJiaoti Huang
Jan 26, 2021·Cellular Oncology (Dordrecht)·Clara LemosBernard Haendler
May 29, 2021·Analytical Chemistry·Artem PlissParas N Prasad
Jun 16, 2021·Biochemical Pharmacology·Kush K Patel, Khosrow Kashfi
Jul 21, 2021·Nutrition and Cancer·Eric Francisco Contreras-LópezRosa María Oliart-Ros
Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Bárbara MatosMargarida Fardilha
Aug 28, 2021·Diagnostics·Lyudmila V Bel'skayaVictor K Kosenok

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