Lipid peroxidation and cardiac troponin T release during routine cardiac surgery

Cardiology
G InselmannU Nellessen

Abstract

Myocardial injury after cardiac surgery with cardiopulmonary bypass may be related to free oxygen radical-induced lipid peroxidation. The purpose of this study was to monitor perioperative changes of cardiac troponin t and malondialdehyde as an indicator of lipid peroxidation in patients who underwent routine cardiac operation and had no signs of perioperative myocardial infarction. Patients with thoracic surgery alone served as controls. We studied 20 patients with cardiopulmonary bypass (CPB) and 9 patients with other thoracic operations. Serum troponin t, malondialdehyde, myoglobin, creatine kinase (CK) including CK-MB isoenzyme levels were monitored before CPB, immediately after cessation of CPB, 20 and 44 h after CPB. Patients with signs of myocardial infarction before or up to 44 h after surgery were excluded. Of 20 patients with CBP, 18 patients showed a significant increase of troponin t and 16 patients had elevated malondialdehyde serum levels following CPB. Troponin t serum values were raised immediately after CPB to 0.60 +/- 0.12 microg/l and increased further to 0.90 +/- 0.17 microg/l after 44 h (p < 0.005, in comparison to preoperative: 0.08 +/- 0.02 microg/l). Patients undergoing the other thoracic operations show...Continue Reading

Citations

Jun 25, 2002·The Annals of Thoracic Surgery·Subramaniam BalachandranPeter Hobson
Feb 13, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·M S AvidanR A Sherwood
May 3, 2002·Journal of the American College of Cardiology·James L JanuzziElizabeth Lee-Lewandrowski
May 22, 2013·Journal of Environmental and Public Health·Samaneh KhademikiaAmir Modaberi
Dec 10, 2002·Scandinavian Cardiovascular Journal : SCJ·Vittorio MantovaniMario Viganó
Feb 22, 2011·Free Radical Biology & Medicine·Frederic T BillingsMias Pretorius
Aug 1, 2007·Asian Cardiovascular & Thoracic Annals·Madan M Maddali, Muthukkumar C Rajakumar

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