Lipid peroxidation and covalent binding in the early functional impairment of liver Golgi apparatus by carbon tetrachloride

Cell Biochemistry and Function
G PoliM U Dianzani

Abstract

The onset of the lipoprotein secretory block provoked by CCl4 in the whole animal was monitored after purification of liver Golgi membranes. Both lipid transit through the apparatus and hexosylation of the lipoprotein are markedly inhibited 5-15 min after poisoning. Pre-treating the animal with alpha-tocopherol, shown to prevent lipid peroxidation without modifying the covalent binding due to CCl4 metabolites, affords little protection against lipid accumulation in the Golgi, but total preservation of galactosyl transferase activity. While haloalkylation therefore appears to be the major mechanism of damage in the early phases of CCl4-induced derangement of lipid secretion, lipid peroxidation is probably more involved later; this is indicated by the marked, though never complete, protection against fatty liver afforded at 24 h after CCl4 poisoning by supplementation of the membrane with alpha-tocopherol.

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Citations

Jan 1, 1993·Molecular Aspects of Medicine·K H Cheeseman
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·D CottalassoG Nanni
Apr 1, 1994·Occupational and Environmental Medicine·D CottalassoG Nanni
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Jan 30, 2004·Journal of Gastroenterology and Hepatology·Kutbeddin DemirdagAhmet Kalkan
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ParolaM U Dianzani
Sep 24, 2005·Physics in Medicine and Biology·Mikko S LaasanenJukka S Jurvelin
Mar 1, 1994·The Proceedings of the Nutrition Society·D I Thurnham
Jan 1, 1994·Nutrition Research Reviews·C J Bates, H Heseker

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