Abstract
The onset of the lipoprotein secretory block provoked by CCl4 in the whole animal was monitored after purification of liver Golgi membranes. Both lipid transit through the apparatus and hexosylation of the lipoprotein are markedly inhibited 5-15 min after poisoning. Pre-treating the animal with alpha-tocopherol, shown to prevent lipid peroxidation without modifying the covalent binding due to CCl4 metabolites, affords little protection against lipid accumulation in the Golgi, but total preservation of galactosyl transferase activity. While haloalkylation therefore appears to be the major mechanism of damage in the early phases of CCl4-induced derangement of lipid secretion, lipid peroxidation is probably more involved later; this is indicated by the marked, though never complete, protection against fatty liver afforded at 24 h after CCl4 poisoning by supplementation of the membrane with alpha-tocopherol.
References
May 15, 1979·The Biochemical Journal·A BenedettiM Comporti
Aug 23, 1979·Biochimica Et Biophysica Acta·J J Bergeron
Feb 1, 1979·Experimental and Molecular Pathology·G PoliM U Dianzani
Apr 19, 1979·Nature·J E PackerR L Willson
Feb 15, 1979·The Biochemical Journal·E GravelaT F Slater
Dec 1, 1977·Analytical Biochemistry·G L Peterson
Feb 1, 1978·FEBS Letters·U M MarinariG Nanni
Jan 1, 1987·Free Radical Research Communications·K H CheesemanT F Slater
Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·W J BrattinR O Recknagel
Feb 11, 1985·Life Sciences·G PoliM U Dianzani
Jan 1, 1985·Lipids·G W BurtonK U Ingold
Oct 1, 1969·The Journal of Cell Biology·B FleischerH Ozawa
Oct 1, 1973·The Journal of Cell Biology·J H EhrenreichG E Palade
Oct 1, 1973·The Journal of Cell Biology·J J BergeronG E Palade
Aug 1, 1974·Chemico-biological Interactions·A BenedettiM Comporti
Apr 1, 1971·The Biochemical Journal·F M BaccinoM F Zuretti
Apr 1, 1969·Experimental and Molecular Pathology·K S Rao, R O Recknagel
Oct 1, 1981·Chemico-biological Interactions·G PoliM U Dianzani
Aug 15, 1984·The Biochemical Journal·T F Slater
Jan 11, 1984·Biochimica Et Biophysica Acta·J A TaylorJ D Judah
Jun 15, 1983·The Biochemical Journal·F P CorongiuA Milia
Aug 1, 1955·The Biochemical Journal·C DE DUVEF APPELMANS
Citations
Jan 1, 1993·Molecular Aspects of Medicine·K H Cheeseman
May 31, 1994·Toxicology·E G VallesJ A Castro
Dec 15, 1995·Toxicology·D CottalassoG Nanni
Feb 7, 2001·Toxicology·D CottalassoG Nanni
Nov 16, 2006·Stem Cells and Development·Yun-Jae JungHo-Seong Han
Jun 11, 1998·Alcoholism, Clinical and Experimental Research·D CottalassoG Nanni
Apr 1, 1994·Occupational and Environmental Medicine·D CottalassoG Nanni
Apr 22, 2014·Archives of Toxicology·Gisela CamposPatricio Godoy
Jan 1, 1990·Free Radical Research Communications·M A PronzatoU M Marinari
Apr 24, 2003·Critical Reviews in Toxicology·Lutz W D WeberAndreas Stampfl
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Kutbeddin DemirdagAhmet Kalkan
Aug 24, 1992·FEBS Letters·M ParolaG Poli
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M ParolaM U Dianzani
Sep 24, 2005·Physics in Medicine and Biology·Mikko S LaasanenJukka S Jurvelin
Mar 1, 1994·The Proceedings of the Nutrition Society·D I Thurnham
Apr 1, 1996·The British Journal of Nutrition·F R Van Der KlisF A Muskiet
Jan 1, 1994·Nutrition Research Reviews·C J Bates, H Heseker
Apr 1, 1991·Cell Biochemistry and Function·F BiasiG Poli
Nov 21, 1997·Annals of Clinical Biochemistry·A B HalimA Darwish
Sep 28, 1990·Biochemical and Biophysical Research Communications·M A PronzatoG Poli