Lipid Peroxidation and Immune Biomarkers Are Associated with Major Depression and Its Phenotypes, Including Treatment-Resistant Depression and Melancholia

Neurotoxicity Research
Magdalena Sowa-KucmaM Maes

Abstract

To examine immune-inflammatory and oxidative (I&O) biomarkers in major depression (MDD) and its related phenotypes, we recruited 114 well-phenotyped depressed patients and 50 healthy controls and measured serum levels of interleukin (IL)-1α, soluble IL-1 receptor antagonist (sIL-1RA), soluble IL-2 receptor (sIL-2R), soluble IL-6 receptor (sIL-6R), soluble tumor necrosis factor receptor 60 and 80 kDa (sTNF-R1/R2), and thiobarbituric acid reactive substances (TBARS). Obtained results indicate that MDD is characterized by increased sIL-1RA, sTNF-R1, and TBARS concentrations. Melancholic depression is associated with increased sIL-6R but lowered IL-1α levels. A current episode of depression is accompanied by significantly increased sIL-6R compared to the remitted state. Treatment-resistant depression (TRD) is accompanied by increased sIL-6R and TBARS but lowered sTNF-R2 levels compared to non-TRD patients. These immune markers are not significantly correlated with Hamilton Depression Rating Scale (HDRS), Montgomery-Asberg Depression Scale (MADRS), number episodes, or age at onset. Our findings show that increased sIL-1RA, sTNF-R1, and TBARS levels may be trait markers of depression, while increased sIL-6R levels may be a state mark...Continue Reading

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Citations

Apr 4, 2018·Molecular Neurobiology·Michael Maes, Andre F Carvalho
Dec 2, 2020·Journal of Clinical Medicine·Aleksander NobisNapoleon Waszkiewicz
Oct 1, 2020·International Journal of Molecular Sciences·Mikhail V VoroninSergei B Seredenin
Sep 27, 2020·Molecular and Cellular Neurosciences·Virginie RappeneauChadi Touma
Apr 9, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Fatemeh JafariReza Amani
Apr 17, 2021·The European Journal of Neuroscience·Giedre ValiulieneArunas Germanavicius
Apr 28, 2021·Biological Trace Element Research·Mehran Shayganfard

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Methods Mentioned

BETA
MDA
pharmacotherapies
enzyme-linked immunoassay
Assay

Software Mentioned

Gen5

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