PMID: 2105411Jan 1, 1990Paper

Lipid peroxidation and lung ultrastructural changes in an experimental model of leukocyte-mediated pulmonary injury

Lung
E BorrelliA Grossi

Abstract

The aim of this study was to study ultrastructural changes and lipid peroxidation in rabbits lung after massive complement activation and leukocyte aggregation. A prolonged and massive leukocyte activation was induced by intraperitoneal inoculation of zymosan suspected in paraffin. Fifteen animals (group 3) were given 0.6 g/kg of zymosan, 22 animals (group 2) received 1 g/kg, and 11 rabbits (group 1) were treated with paraffin alone and served as controls. An acute mortality rate of 40% was observed in group 3 and of 68% in group 2. Surviving animals were studied for 10 days. In these animals a marked decrease in circulating granulocytes and a progressive decline in arterial PO2 were recorded (PO2 on day 10 in group 2 animals was 51.94 +/- 4.26, p less than 0.01). Microscopic and ultrastructural evaluation revealed sequestration of granulocytes in the pulmonary microvasculature. Studies of lung homogenates demonstrated increased levels of lipid peroxide derivative malondialdehyde (group 2 rabbits, 1624 +/- 638; group 1, 795 +/- 57 pm/mg pt, p less than .001) and decreased levels of the tissue antioxidant alpha-tocopherol. The results of this study are compatible with the hypothesis of leukocyte-mediated injury through productio...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
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Citations

Jun 1, 1992·American Journal of Respiratory Cell and Molecular Biology·K KobayashiA Wanner
Sep 1, 1992·European Journal of Pediatrics·L SchrodM Kirschfink
Oct 17, 1998·Journal of Veterinary Internal Medicine·D J Weiss, J Rashid

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