Lipid peroxidation depends on the clock 3111T/C gene polymorphism in menopausal women with Insomnia

Chronobiology International
Natalya SemenovaLubov Kolesnikova

Abstract

A comparative analysis of lipid peroxidation processes and antioxidant defense system in Caucasian menopausal women with/without insomnia depending on the genotype of Clock 3111T/C gene polymorphism was performed. Two hundred and fourteen Caucasian menopausal women divided into control (without insomnia) and main group (with insomnia) were examined. Lipid peroxidation (conjugated dienes, thiobarbituric acid reactants) and antioxidant defense system parameters (?-tocopherol, retinol, reduced and oxidized glutathione, glutathione S-transferase, glutathione peroxidase, glutathione reductase, superoxide dismutase) were determined by spectrofluorophotometer and immunoenzymometric methods. Patients with insomnia carriers of the TT-genotype had a significantly higher thiobarbituric acid reactants level and glutathione peroxidase activity as compared to group with insomnia carriers of the minor 3111C-allele (p < .05). A comparative analysis of the parameters in the women of the main and control groups showed higher conjugated dienes, thiobarbituric acid reactants levels and lower retinol, reduced glutathione levels, glutathione reductase activity in women with insomnia carriers of the TT-genotype (p < .05). The carriers of the minor al...Continue Reading

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Citations

Feb 6, 2020·International Journal of Molecular Sciences·Xiaoyue PanSamantha Mota
Apr 10, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N V SemenovaL I Kolesnikova

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