PMID: 8937879Jan 1, 1996Paper

Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model

Free Radical Biology & Medicine
F AntunesR E Pinto

Abstract

An integrative mathematical model was developed to obtain an overall picture of lipid hydroperoxide metabolism in the mitochondrial inner membrane and surrounding matrix environment. The model explicitly considers an aqueous and a membrane phase, integrates a wide set of experimental data, and unsupported assumptions were minimized. The following biochemical processes were considered: the classic reactional scheme of lipid peroxidation; antioxidant and pro-oxidant effects of vitamin E; pro-oxidant effects of iron; action of phospholipase A2, glutathione-dependent peroxidases, glutathione reductase and superoxide dismutase; production of superoxide radicals by the mitochondrial respiratory chain; oxidative damage to proteins and DNA. Steady-state fluxes and concentrations as well as half-lives and mean displacements for the main metabolites were calculated. A picture of lipid hydroperoxide physiological metabolism in mitochondria in vivo showing the main pathways is presented. The main results are: (a) perhydroxyl radical is the main initiation agent of lipid peroxidation (with a flux of 10(-7)MS-1); (b) vitamin E efficiently inhibits lipid peroxidation keeping the amplification (kinetic chain length) of lipid peroxidation at lo...Continue Reading

References

Jul 1, 1979·Physiological Reviews·B ChanceA Boveris
Oct 1, 1978·Photochemistry and Photobiology·B A SvingenS D Aust
Oct 10, 1977·Biochemical and Biophysical Research Communications·M H Klapper
Oct 1, 1977·Archives of Biochemistry and Biophysics·F H StultsA L Tappel
Sep 1, 1992·Mutation Research·C Richter
Nov 1, 1992·Chemistry and Physics of Lipids·P F Wang, R L Zheng
Jul 1, 1990·Journal of Biochemistry·K KurosawaK Tagawa
Dec 15, 1989·The Biochemical Journal·O I AruomaB Halliwell
Jan 1, 1989·Free Radical Biology & Medicine·A L TappelC G Fraga
Jan 1, 1989·Free Radical Biology & Medicine·I A ClarkW B Cowden
Jan 1, 1989·Free Radical Biology & Medicine·N J Schisler, S M Singh
Mar 1, 1988·Chemical Research in Toxicology·D T SawyerK S Yamaguchi
Jun 11, 1987·The American Journal of Physiology·A ClarkC R Honig
Jan 1, 1987·Critical Reviews in Toxicology·A A Horton, S Fairhurst
Nov 1, 1987·Chemistry and Physics of Lipids·F R Ungemach
Mar 17, 1988·Biochimica Et Biophysica Acta·K Olafsdottir, D J Reed
Sep 15, 1988·Biochemical and Biophysical Research Communications·K MukaiK Ishizu
May 1, 1985·Biochemical Pharmacology·P C Jocelyn, A Cronshaw
Aug 30, 1985·Science·G D RoseM H Zehfus
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·C R Hackenbrock
Aug 1, 1972·The Journal of Cell Biology·A R Gear, J M Bednarek
Sep 1, 1973·Archives of Biochemistry and Biophysics·H J Forman, I Fridovich
Jan 1, 1964·Biochemical and Biophysical Research Communications·P HochsteinL Ernster
Jul 1, 1972·The Biochemical Journal·A BoverisB Chance
Apr 1, 1972·Journal of the American Geriatrics Society·D Harman

❮ Previous
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Citations

Jul 20, 2006·Pharmaceutical Research·Teh-Min HuSusan R Mallery
Mar 3, 2004·Archives of Biochemistry and Biophysics·Andrew M JamesMichael P Murphy
Jun 1, 2005·Mechanisms of Ageing and Development·Andrew M JamesMichael P Murphy
Jan 5, 2000·Bioelectrochemistry and Bioenergetics·A D de Grey
Nov 14, 2001·Free Radical Biology & Medicine·A SalvadorR E Pinto
Jan 25, 2003·Free Radical Biology & Medicine·Luisa CyrneH Susana Marinho
Nov 4, 1998·Free Radical Biology & Medicine·H NohlA V Kozlov
Jun 4, 2002·DNA and Cell Biology·Aubrey D N J De Grey
May 9, 2006·Antioxidants & Redox Signaling·James R Stone, Suping Yang
Aug 2, 2007·Antioxidants & Redox Signaling·Fernando AntunesEnrique Cadenas
Jan 29, 2008·Antioxidants & Redox Signaling·Hugo P MonteiroLuiz R Travassos
Apr 14, 2009·Antioxidants & Redox Signaling·Derick HanNeil Kaplowitz
Aug 10, 2002·Journal of Cellular and Molecular Medicine·Cécile BatandierX M Leverve
May 9, 2008·American Journal of Physiology. Cell Physiology·Behnam SaberiDerick Han
Jun 20, 2000·FEBS Letters·F Antunes, E Cadenas
Dec 23, 2006·The Journal of Investigative Dermatology·Hue-Tran Hornig-DoMatthias Schauen
Jan 4, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Chuan XueAvner Friedman
Sep 4, 2015·Bioelectromagnetics·Alexey KipriyanovPeter Purtov
Jan 15, 2015·Toxicological Research·Aekyong Kim
Jun 13, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mihaela RaduAnca Dinischiotu
Sep 25, 2012·Free Radical Research·Saptarshi KarMahendra Kavdia
Nov 6, 2008·Expert Opinion on Drug Safety·Kalyanasundaram SubramanianSrivatsan Raghunathan
Jul 23, 2015·North American Journal of Medical Sciences·Md Faruk HossainHossain Uddin Shekhar
Jul 24, 2013·Bioorganic & Medicinal Chemistry·Luca BamontiLars Gille
Aug 13, 2013·Redox Biology·Brett A WagnerGarry R Buettner
Apr 20, 2010·Chemistry and Physics of Lipids·Nazha Sidahmed-AdrarFabrice Collin
May 4, 2017·Antioxidants & Redox Signaling·Matilde MaiorinoFulvio Ursini
Dec 3, 2003·The Journal of Biological Chemistry·Miguel R BrancoFernando Antunes
Dec 23, 1999·The Journal of Biological Chemistry·J J PoderosoA Boveris

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