PMID: 2116179Jul 16, 1990Paper

Lipid peroxidation in the liver of carcinogen-resistant rats

Biochimica Et Biophysica Acta
H HammadY Sakamoto

Abstract

Recently, we developed a new strain of rats that exhibit marked resistance to the hepatotoxic and carcinogenic actions of 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) and some other carcinogens. In this work, we compared lipid peroxidation in the liver of these carcinogen-resistant (R) rats and the parental Donryu strain rats that are sensitive (S) to hazardous actions of these carcinogens. The liver microsomal fractions of the R group contained less amounts of polyunsaturated fatty acids. Microsomal lipid peroxidation in the presence of exogenous NADPH was much lower in R rats than in S rats. Liver microsomes of R rats were much less active than those of S rats also in producing 4-hydroxynonenal, carbonyl compounds and conjugated diene. The hepatic contents of ascorbic acid, glutathione, alpha-tocopherol and coenzyme Q in the R rats were similar to those in S rats. The activities of the free radical scavenger enzymes, superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT), in the two groups were also similar. Alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) are both thought to function in disposal of these cytotoxic aldehydes. The liver microsomal and mitochondrial ALDH activities of the ...Continue Reading

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Citations

Jul 18, 2008·Histochemistry and Cell Biology·Takahiro GotowYasuo Uchiyama
Aug 1, 1992·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·R Dargel
Feb 9, 2000·Japanese Journal of Cancer Research : Gann·S Mise-OmataU Yamashita
Nov 15, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Cristina Trejo-SolísRolando Hernández-Muñoz

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