Lipid peroxidation/antioxidant activity in patients with alopecia areata

Journal of the European Academy of Dermatology and Venereology : JEADV
N S A Abdel FattahE S El Okda

Abstract

Aetiopathogenesis of alopecia areata (AA) is not fully understood and many factors have been assumed. Oxidant/antioxidant disequilibrium has been proposed with controversies between results. The aim of this study was to determine lipid peroxidation/antioxidant activity in patients with AA and to determine its clinical significance. Fifty non-obese patients with AA and 50 age-, gender- and body mass index-matched controls (25 patients with severe grade acne vulgaris representative of an oxidative stress condition and 25 healthy volunteers), were included. Levels of malondialdehyde (MDA), indicator of lipid peroxidation and antioxidant activity of superoxide dismutase (SOD), were spectrophotometrically measured in blood from all subjects and in scalp tissues from 10 patients with AA. No significant differences in MDA levels and SOD activity existed between patients with AA and those with acne. However, significantly higher MDA levels and lower SOD activity were found in patients with AA compared with healthy controls. Within patients with AA, lipid peroxidation/antioxidant parameters showed significant differences with disease duration, pattern and extent of lesions. Significant positive correlations also existed between tissue a...Continue Reading

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Citations

Jul 24, 2012·Biological Trace Element Research·Mustafa NazıroğluManuel Flores-Arce
Jul 11, 2013·American Journal of Clinical Dermatology·Ola Ahmed BakryAmira Gooda
Mar 19, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Abdullateef A AlzolibaniAhmad A Al Robaee
Apr 18, 2013·Cutaneous and Ocular Toxicology·Serap Gunes BilgiliMehmet Aslan
Aug 5, 2015·Bioscience, Biotechnology, and Biochemistry·Natsumi TasakiHiromi Sanada
Sep 19, 2012·Skin Pharmacology and Physiology·R RamadanD Tawfik
Dec 27, 2019·International Journal of Dermatology·Prakash Acharya, Mahesh C Mathur
Mar 17, 2017·Nature Reviews. Disease Primers·C Herbert PrattJohn P Sundberg
May 9, 2021·Mycoses·Mahmut Sami MetinTorello Lotti
May 27, 2021·Journal of Cosmetic Dermatology·Soumya SachdevaKabir Sardana

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