Lipid polymorphism of model and cellular membranes as revealed by electron microscopy

Electron Microscopy Reviews
V L Borovyagin, A G Sabelnikov

Abstract

This review surveys the current state of knowledge relating to lipid polymorphism within both model lipid membrane and cellular membrane systems. Emphasis is placed upon the contribution of data obtained by transmission electron microscopy of freeze-fractured specimens. Some consideration is also given to the other important methods for the study of lipid polymorphism, namely X-ray diffraction and NMR spectroscopy. A detailed account of the different phases found in lipid mixtures within model membranes (bilayer, cubic or tetragonal, tubular or hexagonal) provides the background to the understanding of the factors involved in polymorphic phase transitions. The sequential steps involved in lipid polymorphism are defined from electron microscopical data and are related to the structural changes that can be detected within biological membranes. It is proposed that the fine structural changes detected at the initial stages of polymorphic transition in vivo may be highly relevant in relation to membrane fusion events, to the formation of tight junctions, and even to physiological transport processes. Since the later stages of polymorphic transition generally destroy the permeability barrier of model and cellular membranes, extensive...Continue Reading

References

Jan 1, 1978·Annals of the New York Academy of Sciences·D PapahadjopoulosW Pangborn
Dec 20, 1979·Biochimica Et Biophysica Acta·P R Cullis, B de Kruijff
May 10, 1979·Nature·A J VerkleijP H Ververgaert
Dec 12, 1979·Biochimica Et Biophysica Acta·W J De GripA J Verkleij
Jun 16, 1977·Biochimica Et Biophysica Acta·N Düzgüneş, S Ohki
Oct 20, 1987·Biochemistry·H TournoisB de Kruijff
Dec 1, 1987·Biochemical Society Transactions·R A de Maagd, B J Lugtenberg
Mar 22, 1988·Biochimica Et Biophysica Acta·K N BurgerA J Verkleij
Apr 1, 1986·Journal of Ultrastructure and Molecular Structure Research·K Asami
Jun 1, 1986·Chemistry and Physics of Lipids·P R CullisC P Tilcock
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S M Gruner
Mar 15, 1985·Biochemical and Biophysical Research Communications·A G SabelnikovI A Vasilenko
Oct 1, 1968·Proceedings of the National Academy of Sciences of the United States of America·C R Hackenbrock
Jan 1, 1974·The Journal of Cell Biology·J A McIntyreM J Karnovsky
Feb 11, 1972·Biochimica Et Biophysica Acta·R P Rand, S Sengupta
Jun 1, 1972·The Journal of Cell Biology·D S Friend, N B Gilula
Jan 1, 1973·The Journal of Cell Biology·B SatirP Satir
Feb 26, 1974·Biochimica Et Biophysica Acta·D AtkinsonJ M Stubbs
Jul 15, 1969·Biochimica Et Biophysica Acta·E Junger, H Reinauer
Dec 1, 1984·Journal of Ultrastructure Research·V L BorovyaginI A Vasilenko
Nov 18, 1980·Biochimica Et Biophysica Acta·B de Kruijff, P R Cullis
Mar 1, 1981·The Journal of Cell Biology·J E Heuser, T S Reese
May 1, 1981·Cell Biology International Reports·H Plattner
Jun 1, 1983·Canadian Journal of Biochemistry and Cell Biology = Revue Canadienne De Biochimie Et Biologie Cellulaire·R M Tanguay
Jan 27, 1984·Biochimica Et Biophysica Acta·A J Verkleij
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·W J Gordon-Kamm, P L Steponkus
Mar 1, 1982·Cell·P Pinto da Silva, B Kachar

❮ Previous
Next ❯

Citations

Oct 1, 1992·Chemistry and Physics of Lipids·A OrtizJ C Gómez-Fernandez
Jan 1, 1994·Progress in Biophysics and Molecular Biology·A G Sabelnikov
Jan 25, 2003·Biochimica Et Biophysica Acta·Alexey AgafonovGalina D Mironova
Jul 1, 1991·Biochimica Et Biophysica Acta·A G SabelnikovV L Borovyagin
Feb 13, 2008·Journal of Cellular and Molecular Medicine·Pablo V EscribáGwendolyn Barceló-Coblijn
Sep 21, 2006·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sergii AfoninAnne S Ulrich
Jun 18, 2003·Journal of Lipid Research·Jesús PradesFrancisca Barceló
Jul 22, 1996·FEBS Letters·T S TarahovskyG R Ivanitsky
Jan 4, 2003·Hypertension·Pablo V EscribáValentina Ruiz-Gutiérrez

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.