Lipid Profiling of Peri-implantation Endometrium in Patients With Premature Progesterone Rise in the Late Follicular Phase

The Journal of Clinical Endocrinology and Metabolism
Jingjie LiHuichang Bi

Abstract

Late follicular phase elevation in serum progesterone (P) during controlled ovarian hyperstimulation negatively affects the outcome of assisted reproductive technology by contributing to endometrial-embryo asynchrony. There are still no data on lipid metabolite alterations during this process. To investigate alterations in the lipid profile during the window of implantation in patients with premature P rise. Lipidomic variations in the endometrium were evaluated by ultrahigh-performance liquid chromatography coupled with electrospray ionization high-resolution mass spectrometry. University assisted reproductive medicine unit. Forty-three patients undergoing in vitro fertilization/intracytoplasmic sperm injection because of a tubal factor or male factor infertility were included in this study. The patients were divided into a high P group (P ≥ 1.5 ng/mL, 15 patients) and a normal P group (P < 1.5 ng/mL, 28 patients) on the day of human chorionic gonadotropin administration. The endometrial tissues were obtained by Pipelle biopsy 7 days after human chorionic gonadotropin administration. Alterations in lipid metabolites. A total of 1026 ions were identified, and 25 lipids were significantly upregulated. The endometrial lipid profi...Continue Reading

References

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Citations

Dec 23, 2019·Journal of Assisted Reproduction and Genetics·Roberto MatorrasCristina Alonso
Jul 6, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Henri F Avela, Heli Sirén

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