Lipid rafts: contentious only from simplistic standpoints.

Nature Reviews. Molecular Cell Biology
John F Hancock

Abstract

The hypothesis that lipid rafts exist in plasma membranes and have crucial biological functions remains controversial. The lateral heterogeneity of proteins in the plasma membrane is undisputed, but the contribution of cholesterol-dependent lipid assemblies to this complex, non-random organization promotes vigorous debate. In the light of recent studies with model membranes, computational modelling and innovative cell biology, I propose an updated model of lipid rafts that readily accommodates diverse views on plasma-membrane micro-organization.

References

Jun 5, 1997·Nature·K Simons, E Ikonen
Nov 21, 1997·Biochemical and Biophysical Research Communications·D A Brown, E London
Jun 9, 1999·Proceedings of the National Academy of Sciences of the United States of America·A SubtilT E McGraw
May 16, 2000·The Journal of Biological Chemistry·M Hao, F R Maxfield
Feb 27, 2001·Biophysical Journal·C DietrichE Gratton
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·C DietrichK Jacobson
Jun 12, 2002·The Journal of Cell Biology·Takahiro FujiwaraAkihiro Kusumi
Nov 5, 2002·Biophysical Journal·H Heerklotz
Jan 16, 2003·The Journal of Cell Biology·Ian A PriorJohn F Hancock
Jan 25, 2003·Annual Review of Biophysics and Biomolecular Structure·Michael Edidin
Feb 8, 2003·Annual Review of Biophysics and Biomolecular Structure·Harden M McConnell, Marija Vrljic
Mar 22, 2003·Biochimica Et Biophysica Acta·Harden M McConnell, Arun Radhakrishnan
Apr 3, 2003·Journal of the American Chemical Society·Daniel HusterKlaus Arnold
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Leonard J FosterMatthias Mann
Jun 6, 2003·Journal of Molecular Biology·Heiko HeerklotzJoachim Seelig
Sep 26, 2003·Biophysical Journal·Rodrigo F M de AlmeidaManuel Prieto
Nov 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jeanne KwikMichael Edidin
Nov 19, 2003·Cell·Sean Munro
Dec 3, 2003·European Biophysics Journal : EBJ·Amy C RowatJohn H Ipsen
Jan 22, 2004·The Journal of Biological Chemistry·Mingming HaoFrederick R Maxfield
Mar 16, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kakoli MitraDonald M Engelman
Mar 20, 2004·Traffic·Satyajit Mayor, Madan Rao
Apr 28, 2004·Biophysical Journal·S L VeatchS L Keller
May 5, 2004·Proceedings of the National Academy of Sciences of the United States of America·Hideji MurakoshiAkihiro Kusumi
May 14, 2004·Annual Review of Biophysics and Biomolecular Structure·Kai Simons, Winchil L C Vaz
Jun 17, 2004·Journal of the American Chemical Society·Sascha JanoschRoland Winter
Jul 16, 2004·Molecular and Cellular Biology·Barak RotblatJohn F Hancock
Aug 10, 2004·Biophysical Journal·Sagar A PanditH L Scott
Nov 3, 2004·Biochimica Et Biophysica Acta·Harald Pichler, Howard Riezman
Nov 3, 2004·Biochimica Et Biophysica Acta·Morten Ø Jensen, Ole G Mouritsen
Nov 19, 2004·Journal of the American Chemical Society·Alemayehu A GorfeAmedeo Caflisch
Jan 26, 2005·The Journal of Cell Biology·Matthew KirkhamRobert G Parton

❮ Previous
Next ❯

Citations

Apr 28, 2009·Journal of Physiology and Biochemistry·E M Danielsen, G H Hansen
Jul 14, 2007·Cellular and Molecular Life Sciences : CMLS·J OmerovicI A Prior
Aug 18, 2012·The Journal of Membrane Biology·Aneta Dorota Petelska, Zbigniew Artur Figaszewski
Jul 26, 2008·European Biophysics Journal : EBJ·James DugganHelen Harris
Jul 17, 2012·Molecular Genetics and Genomics : MGG·Agustina Olivera-Couto, Pablo S Aguilar
Oct 13, 2010·Protoplasma·Jens TilsnerLesley Torrance
Aug 19, 2007·Cell Biochemistry and Biophysics·Philip LeDuc, Russell Schwartz
Sep 15, 2010·Brain Research·Amy M NavratilMark S Roberson
May 22, 2008·The British Journal of Nutrition·Robert S ChapkinJoanne R Lupton
Apr 9, 2011·Journal of the American Chemical Society·Jason D Perlmutter, Jonathan N Sachs
Aug 10, 2012·Journal of the American Chemical Society·Tsutomu HamadaMasahiro Takagi
Sep 4, 2012·Journal of the American Chemical Society·Laura B SagleRichard P Van Duyne
Sep 22, 2012·Journal of the American Chemical Society·Zhenlong LiAlemayehu A Gorfe
Mar 22, 2013·Journal of the American Chemical Society·Mónica M LozanoSteven G Boxer
Feb 8, 2013·The Journal of Physical Chemistry. B·Aundrea R Piper-FeldkampScott M Reed
Apr 21, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Paul A BealesT Kyle Vanderlick
Apr 25, 2012·Cell Research·Xinwang CaoKai Simons
Jun 2, 2007·Nature Cell Biology·John F Hancock
Jul 10, 2007·Nature Cell Biology·Tianhai TianJohn F Hancock
Nov 21, 2007·Nature Cell Biology·Nagaraj BalasubramanianMartin Alexander Schwartz
Dec 22, 2009·Nature Cell Biology·Helge EwersLudger Johannes
May 17, 2011·Nature Cell Biology·Eugene TkachenkoMark H Ginsberg
Jul 22, 2008·Nature Chemical Biology·Rémi LasserreHai-Tao He
Aug 22, 2012·Nature Chemical Biology·John R Silvius
Jul 6, 2007·Nature Clinical Practice. Neurology·Haipeng ChengGopal Thinakaran
Oct 21, 2006·Nature Immunology·Andrey S Shaw
Sep 15, 2007·Nature Protocols·Daniel Lingwood, Kai Simons
Oct 4, 2008·Nature Protocols·Marie-Paule Mingeot-LeclercqYves F Dufrêne
Feb 24, 2007·Nature Reviews. Molecular Cell Biology·Robert G Parton, Kai Simons
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
May 25, 2010·Nature Reviews. Molecular Cell Biology·Boris N KholodenkoWalter Kolch
Sep 24, 2010·Nature Reviews. Molecular Cell Biology·Kai Simons, Mathias J Gerl
Dec 30, 2006·Nature Reviews. Neuroscience·John A AllenMark M Rasenick
Sep 21, 2007·Nature Reviews. Neuroscience·Daniele PiomelliRao Rapaka
Jul 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Daniel LingwoodKai Simons
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Hermann-Josef KaiserKai Simons
Mar 31, 2010·Proceedings of the National Academy of Sciences of the United States of America·Steffen J SahlChristian Eggeling
Jan 6, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lars V SchäferSiewert J Marrink
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Lorant JanosiAlemayehu A Gorfe
Dec 5, 2009·The Journal of Biological Chemistry·Abedelnasser AbulrobLinda J Johnston

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