Lipid reference values in an Irish population.

Irish Journal of Medical Science
Diarmaid HughesDamian Gerard Griffin

Abstract

There is limited information on reference values for lipids and lipoproteins in an Irish population. In this observational study, we have described the distributions of lipids in a large Irish cohort. Over 110,000 lipid profiles were selected from a database of almost 1.5 million consecutive lipid profiles performed in the Clinical Biochemistry Laboratory in University Hospital Galway between 2004 and 2017 to best represent the Irish population. Age- and sex-related reference intervals for both sexes for total cholesterol, triglycerides, HDL cholesterol and LDL cholesterol, from the age of ten to greater than 90 years, were determined. Two methods for estimating LDL cholesterol were also compared. Sex-related differences in lipid distributions arise before the age of 20 years and are life-long. In both sexes total and LDL cholesterol levels gradually increased towards middle age with a decrease towards old age. Levels tended to be higher in males than in females up to mid-life at which stage they cross over with females having on average higher levels. The median of the triglyceride distributions show similar age- and sex-related changes to total cholesterol, but the distributions show a very marked positive skew that is partic...Continue Reading

References

Jun 1, 1978·European Journal of Clinical Investigation·B LewisG Sigurdsson
Nov 1, 1973·Circulation·L WilhelmsenG Tibblin
Jan 5, 1967·The New England Journal of Medicine·D S FredricksonR S Lees
Jul 18, 2002·Critical Reviews in Clinical Laboratory Sciences·Minna L HannukselaMarkku J Savolainen
Jan 15, 2009·European Heart Journal·Lena BjörckSimon Capewell
Feb 8, 2011·Lancet·Farshad FarzadfarUNKNOWN Global Burden of Metabolic Risk Factors of Chronic Diseases Collaborating Group (Cholesterol)
Jan 27, 2012·The New England Journal of Medicine·Jarett D BerryDonald M Lloyd-Jones
Oct 15, 2013·Clinical Cardiology·Seth S MartinSteven R Jones
Nov 19, 2013·JAMA : the Journal of the American Medical Association·Seth S MartinSteven R Jones
Jan 28, 2015·Circulation·Ann Marie Navar-BogganMichael J Pencina
Aug 28, 2016·European Heart Journal·Alberico L CatapanoUNKNOWN ESC Scientific Document Group
Jul 22, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·V HigginsK Adeli

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Citations

Dec 29, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Marjolein N KooijmanRomy Gaillard

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