Lipid-rich carcinoma of the breast: A report of two cases and a literature review

Oncology Letters
Yizi CongShiguang Zhu

Abstract

Lipid-rich carcinoma of the breast is extremely rare with no standard guidelines for treatment with poor patient prognosis. In the present study, the clinical features, imaging results, pathology, immunohistochemistry, treatment and prognoses of two patients with lipid-rich carcinoma of the breast were analyzed. Two patients were admitted to the Yantai Yuhuangding Hospital Affiliated to the Medical College of Qingdao University (Yantai, Shandong, China) for examination of a palpable mass in the breast. Enlarged lymph nodes were found in the axilla of each patient. The results of mammography and echography imaging suggested the presence of malignancy. A modified radical mastectomy was performed in each patient, and pathological examination revealed atypical large vacuolated cells arranged in clusters and confirmed lipid-rich carcinoma and lymph node metastases. The tumor tissue of patient one was immunohistochemically positive for estrogen receptor (ER), p53, p120 and E-cadherin, and negative for progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER-2), with a Ki-67 labeling index of 50%. The tumor tissue of patient two was immunohistochemically positive for p53, and negative for ER, PR, HER-2 and cytokera...Continue Reading

References

Nov 1, 1985·Pathology, Research and Practice·F Vera-Sempere, A Llombart-Bosch
Dec 1, 1998·Pathology International·Z VargaR Caduff
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Y UmekitaH Yoshida
Mar 15, 2011·Annals of Diagnostic Pathology·Bing GuanXiaojun Zhou
Apr 12, 2012·Journal of breast cancer·Yoshitaka KurisuTakehiro Nohara

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Citations

Oct 18, 2019·International Journal of Surgical Pathology·Mark H KaveshJaya Ruth Asirvatham
Mar 17, 2020·Diagnostic Cytopathology·Charalampos Saganas, Ekkehard Hewer
Mar 24, 2021·Current Oncology Reports·Sarah JenkinsStanley Lipkowitz

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