Lipid sensing and insulin resistance in the brain

Cell Metabolism
Jessica T Y Yue, Tony K T Lam

Abstract

Lipid sensing and insulin signaling in the brain independently triggers a negative feedback system to lower glucose production and food intake. Here, we discuss the underlying molecular and neuronal mechanisms of lipid sensing and insulin signaling in the hypothalamus and how these mechanisms are affected in response to high-fat feeding. We propose that high-fat feeding concurrently disrupts hypothalamic insulin-signaling and lipid-sensing mechanisms and that experiments aimed to restore both insulin action and lipid sensing in the brain could effectively lower glucose production and food intake to restore metabolic homeostasis in type 2 diabetes and obesity.

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Citations

Aug 21, 2013·Reviews in Endocrine & Metabolic Disorders·Beatrice M FilippiTony K T Lam
May 21, 2013·Nature Medicine·Patricia I MighiuTony K T Lam
Aug 21, 2012·Antioxidants & Redox Signaling·Dolors SerraLaura Herrero
Nov 12, 2013·Diabetes & Metabolism·V-S MoulléC Magnan
Dec 29, 2013·Lipids in Health and Disease·Isy F de SousaEliane B Ribeiro
Apr 11, 2014·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mary P LaPierreTony K T Lam
Sep 28, 2014·Molecular and Cellular Endocrinology·Frank A Duca, Jessica T Y Yue
Oct 26, 2014·Reviews in Endocrine & Metabolic Disorders·Jang H Youn
Sep 10, 2014·Diabetes, Obesity & Metabolism·A PicardC Magnan
Sep 30, 2015·Lipids in Health and Disease·Barry Sears, Mary Perry
Sep 30, 2015·Molecular and Cellular Endocrinology·Christophe MagnanSerge Luquet
Aug 12, 2015·Molecular and Cellular Endocrinology·Romana StarkZane B Andrews
Mar 19, 2014·Molecular Metabolism·Mona A AbrahamTony K T Lam
Mar 19, 2014·Molecular Metabolism·Cristina Contreras, Miguel López
Dec 18, 2013·Metabolism: Clinical and Experimental·Jisoo ParkJongsun Park
Nov 26, 2013·Diabetes·Beatrice M FilippiTony K T Lam
Dec 18, 2018·Diabetes/metabolism Research and Reviews·Eliza ChristopoulouMoses Elisaf
Sep 28, 2017·Journal of Inherited Metabolic Disease·Eric S GoetzmanRadhika H Muzumdar
Feb 8, 2019·Biological Chemistry·Chantal ChudobaAndré Kleinridders
Feb 11, 2014·Molecular Endocrinology·Faith K Cragle, Giulia Baldini
May 28, 2019·International Journal of Molecular Sciences·Yuriko NakaokuMasafumi Ihara
Jul 28, 2017·Frontiers in Physiology·A-Karyn JulliardBrigitte Palouzier-Paulignan
Apr 20, 2017·Frontiers in Endocrinology·Kimberley D BruceRobert H Eckel
Dec 15, 2020·American Journal of Physiology. Endocrinology and Metabolism·Jonathan D Schertzer, Tony K T Lam
May 4, 2020·Neuroscience·Nathalia R V DraganoEdward Milbank
Oct 14, 2020·Neuroscience·Nathalia R V DraganoEdward Milbank
Jun 15, 2021·Frontiers in Endocrinology·Andrew FolickMartin Valdearcos

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