Lipid signalling couples translational surveillance to systemic detoxification in Caenorhabditis elegans

Nature Cell Biology
J Amaranath GovindanGary Ruvkun

Abstract

Translation in eukaryotes is followed to detect toxins and virulence factors and coupled to the induction of defence pathways. Caenorhabditis elegans germline-specific mutations in translation components are detected by this system to induce detoxification and immune responses in distinct somatic cells. An RNA interference screen revealed gene inactivations that act at multiple steps in lipid biosynthetic and kinase pathways upstream of MAP kinase to mediate the systemic communication of translation defects to induce detoxification genes. Mammalian bile acids can rescue the defect in detoxification gene induction caused by C. elegans lipid biosynthetic gene inactivations. Extracts prepared from C. elegans with translation deficits but not from the wild type can also rescue detoxification gene induction in lipid-biosynthesis-defective strains. These eukaryotic antibacterial countermeasures are not ignored by bacteria: particular bacterial species suppress normal C. elegans detoxification responses to mutations in translation factors.

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Citations

Apr 3, 2016·The FEBS Journal·Henrique G Colaço, Luis F Moita
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·J Amaranath GovindanGary Ruvkun
Dec 2, 2020·PLoS Biology·Alejandro Vasquez-RifoVictor Ambros

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Methods Mentioned

BETA
transation
transgenic

Software Mentioned

ImageJ
Axiovision
DAVID

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