Oct 19, 2013

Lipid transport and metabolism in healthy and osteoarthritic cartilage

International Journal of Molecular Sciences
Amanda VillalvillaGabriel Herrero-Beaumont

Abstract

Cartilage is an avascular tissue and cartilage metabolism depends on molecule diffusion from synovial fluid and subchondral bone. Thus, nutrient availability is limited by matrix permeability according to the size and charge of the molecules. Matrix composition limits the access of molecules to chondrocytes, determining cell metabolism and cartilage maintenance. Lipids are important nutrients in chondrocyte metabolism and are available for these cells through de novo synthesis but also through diffusion from surrounding tissues. Cartilage status and osteoarthritis development depend on lipid availability. This paper reviews lipid transport and metabolism in cartilage. We also analyze signalling pathways directly mediated by lipids and those that involve mTOR pathways, both in normal and osteoarthritic cartilage.

  • References86
  • Citations19

References

  • References86
  • Citations19

Citations

Mentioned in this Paper

Metabolic Process, Cellular
Biochemical Pathway
Degenerative Polyarthritis
FRAP1 protein, human
Chondrocyte
Synovial Fluid
Metabolic Pathway
Cartilage Diseases
Lipids
Lipid Transport

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