Lipid vesicles in pulsed electric fields: Fundamental principles of the membrane response and its biomedical applications

Advances in Colloid and Interface Science
Dayinta L PerrierPouyan E Boukany

Abstract

The present review focuses on the effects of pulsed electric fields on lipid vesicles ranging from giant unilamellar vesicles (GUVs) to small unilamellar vesicles (SUVs), from both fundamental and applicative perspectives. Lipid vesicles are the most popular model membrane systems for studying biophysical and biological processes in living cells. Furthermore, as vesicles are made from biocompatible and biodegradable materials, they provide a strategy to create safe and functionalized drug delivery systems in health-care applications. Exposure of lipid vesicles to pulsed electric fields is a common physical method to transiently increase the permeability of the lipid membrane. This method, termed electroporation, has shown many advantages for delivering exogenous molecules including drugs and genetic material into vesicles and living cells. In addition, electroporation can be applied to induce fusion between vesicles and/or cells. First, we discuss in detail how research on cell-size GUVs as model cell systems has provided novel insight into the basic mechanisms of cell electroporation and associated phenomena. Afterwards, we continue with a thorough overview how electroporation and electrofusion have been used as versatile meth...Continue Reading

Citations

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Feb 21, 2019·Annual Review of Biophysics·Tadej KotnikDamijan Miklavčič
Jul 21, 2020·Scientific Reports·Gen UrabeSunao Katsuki
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Mar 21, 2018·Scientific Reports·Dayinta L PerrierPouyan E Boukany
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