Lipidome Evolution in Mammalian Tissues

Molecular Biology and Evolution
Ekaterina E KhrameevaPhilipp Khaitovich

Abstract

Lipids are essential structural and functional components of cells. Little is known, however, about the evolution of lipid composition in different tissues. Here, we report a large-scale analysis of the lipidome evolution in six tissues of 32 species representing primates, rodents, and bats. While changes in genes' sequence and expression accumulate proportionally to the phylogenetic distances, <2% of the lipidome evolves this way. Yet, lipids constituting this 2% cluster in specific functions shared among all tissues. Among species, human show the largest amount of species-specific lipidome differences. Many of the uniquely human lipidome features localize in the brain cortex and cluster in specific pathways implicated in cognitive disorders.

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Citations

Jul 28, 2020·Frontiers in Immunology·Sibel KaraAnja Lux
Sep 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mariona JovéReinald Pamplona
Sep 14, 2018·Frontiers in Physiology·Irene PradasReinald Pamplona
Oct 19, 2021·Molecular Biology and Evolution·Benjamin R HarrisonDaniel E L Promislow

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Datasets Mentioned

BETA
GSE43013
GSE30352

Methods Mentioned

BETA
genetic modifications

Software Mentioned

Ensembl
RSEM
OrthoMaM
Spaced words
R package ouch
Ensembl Biomart
Perl
R
STAR

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