Lipidomic Components Alterations of Human Follicular Fluid Reveal the Relevance of Improving Clinical Outcomes in Women Using Progestin-Primed Ovarian Stimulation Compared to Short-Term Protocol

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Xiaowei WenWeiran Chai

Abstract

BACKGROUND Increasing the success rate of in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) is a duty of clinicians that has made many seek a variety of protocols. This study was undertaken to use a liquid chromatography-mass spectrometry (LC-MS) to define the alterations of follicular fluid (FF) lipid metabolites in patients undergoing progestin-primed ovarian stimulation (PPOS) compared with short-term protocol, revealing potential correlations between the differentially expressed lipids and ameliorative clinical outcomes. MATERIAL AND METHODS Ninety-three infertile women undergoing IVF/ICSI treatment with PPOS (n=62) or a short-term protocol (n=31) were prospectively enrolled in a randomized controlled trial. FF samples were obtained from dominant follicles at the time of oocyte retrieval. Lipid metabolism profiles were analyzed using LC-MS. RESULTS Twelve lipids were found to be higher in patients treated with the PPOS protocol than in those receiving the short-term protocol, including triacylglycerols (TAG-34: 1+NH4, TAG-58: 0+NH4, TAG-64: 3+NH4, and TAG-64: 8+NH4), diacylglycerol DAG-38: 6+NH4, phosphatidylglycerols (PG-26: 0, PG-30: 2, and PG-40: 5), phosphatidylethanolamine PE-32: 2, lysophosphatidyleth...Continue Reading

Citations

Oct 24, 2018·International Journal of Molecular Sciences·Priscila Silvana BertevelloSvetlana Uzbekova
May 14, 2020·Reproductive Biology and Endocrinology : RB&E·Xingxing ZhangZhengao Sun
Dec 7, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Zhenni MuYang Yi
Aug 13, 2021·Frontiers in Veterinary Science·Jiayuan MoGanqiu Lan

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Methods Mentioned

BETA
PCA

Software Mentioned

Simca
LipidView
R
Pheatmap

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