Lipidomic evidence that lowering the typical dietary palmitate to oleate ratio in humans decreases the leukocyte production of proinflammatory cytokines and muscle expression of redox-sensitive genes

The Journal of Nutritional Biochemistry
C Lawrence KienMatthew E Poynter

Abstract

We recently reported that lowering the high, habitual palmitic acid (PA) intake in ovulating women improved insulin sensitivity and both inflammatory and oxidative stress. In vitro studies indicate that PA can activate both cell membrane toll-like receptor-4 and the intracellular nucleotide oligomerization domain-like receptor protein (NLRP3). To gain further insight into the relevance to human metabolic disease of dietary PA, we studied healthy, lean and obese adults enrolled in a randomized, crossover trial comparing 3-week, high-PA (HPA) and low-PA/high-oleic-acid (HOA) diets. After each diet, both hepatic and peripheral insulin sensitivities were measured, and we assessed cytokine concentrations in plasma and in supernatants derived from lipopolysaccharide-stimulated peripheral blood mononuclear cells (PBMCs) as well as proinflammatory gene expression in skeletal muscle. Insulin sensitivity was unaffected by diet. Plasma concentration of tumor necrosis factor-α was higher during the HPA diet. Lowering the habitually high PA intake by feeding the HOA diet resulted in lower secretion of interleukin (IL)-1β, IL-18, IL-10, and tumor necrosis factor-α by PBMCs, as well as lower relative mRNA expression of cJun and NLRP3 in muscl...Continue Reading

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Citations

Feb 18, 2016·American Journal of Respiratory Cell and Molecular Biology·Anne E Dixon, Matthew E Poynter
Oct 27, 2017·Nutrients·Priscila Silva FigueiredoPriscila Aiko Hiane
Dec 20, 2017·Antioxidants & Redox Signaling·Susana Rovira-LlopisVictor M Victor
Mar 22, 2018·BMC Biology·Raphaël BoursereauSonia M Brichard
Jul 16, 2017·Biochemical Society Transactions·Anna M KirwanHelen M Roche
Mar 23, 2019·Molecular Biology Reports·Marta WłodarczykGrażyna Nowicka
Dec 7, 2018·Nutrients·Emmanouil KorakasVaia Lambadiari
Apr 4, 2021·International Journal of Molecular Sciences·Gonzalo JorqueraPaola Llanos

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