Feb 6, 2020

Lipidomics dataset of sonication-induced traumatic optic neuropathy in mice

Data in Brief
Ronaldo NuesiSanjoy K Bhattacharya


Traumatic optic neuropathy (TON) is the loss of vision secondary to trauma. Approximately two weeks after traumatic damage, diffuse retinal ganglion cell loss and axon degeneration of the optic nerve are exhibited [1]. Here we present the changes that occur in the optic nerve lipidome of two-month-old C57BL/6J mice following sonication-induced TON (SI-TON), which closely models the indirect clinical mechanism in TON. Optic nerves were harvested at three time points following injury: 1-day, 7-days, and 14-days for comparison with the control group (uninjured optic nerves from 2-month-old mice). The optic nerves were subjected to mass spectrometry and bioinformatic analysis using LipidSearch 4.1.3 and Metaboanalyst 4.0. This data pertains to the lipidome at each time point following indirect trauma to the optic nerve. The data presented here will augment investigation into the neurodegenerative process. The data is available at Metabolomics Workbench [http://www.metabolomicsworkbench.org (Project ID: PR000859)].

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Mentioned in this Paper

OPTN protein, human
Mass Spectrometry
Optic Nerve
Neurodegenerative Disorders
Abnormal Degeneration
C57BL/6 Mouse
Retinal Ganglion Cells
Communicable Diseases

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