Lipidomics revealed idiopathic pulmonary fibrosis-induced hepatic lipid disorders corrected with treatment of baicalin in a murine model

The AAPS Journal
Changfeng HuChengping Wen

Abstract

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease. The current standard treatment with glucocorticoids (GCs) leads to many adverse effects, and its effectiveness is questionable. Thus, it is critical and urgent to find new drug(s) for treatment of IPF. Baicalin (BAI) is an attractive candidate for this purpose. Herein, utilizing shotgun lipidomics, we revealed that IPF could lead to a lipid disorder of the liver in an animal model induced by bleomycin and confirmed through histopathological studies of the lung. Lipidomics further demonstrated that this disorder could virtually be corrected after treatment with BAI, but not with dexamethasone (DEX) (a commonly used GC for treatment of IPF). In contrast, the treatment with DEX did not improve IPF but led to tremendous alterations in hepatic lipidomes and accumulation of fat in the liver, which was very different from the lipid disorder induced by IPF. The underpinning mechanisms of the IPF-resultant lipid disorder and DEX-induced lipotoxicity as revealed by shotgun lipidomics were extensively discussed. Taken together, the current study showed that IPF could lead to hepatic lipid disorder, which can be treated with BAI, and demonstrated that lipidomics could be a powerf...Continue Reading

References

May 6, 1975·European Journal of Biochemistry·S Diamant, E Shafrir
Jan 1, 1991·Archives of Toxicology·J HayG Laurent
Jan 1, 1986·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D AlvaroM Angelico
Sep 1, 1995·Thorax·W MacNee, I Rahman
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·C N WangD N Brindley
Nov 18, 1998·Mayo Clinic Proceedings·J H RyuT E Hartman
Apr 21, 1999·Clinical Science·R C Andrews, B R Walker
Nov 24, 1999·The American Journal of Medicine·G MarchesiniN Melchionda
Feb 1, 2000·Trends in Cell Biology·Y A Hannun, C Luberto
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·S I HagiwaraS Kitamura
Jul 27, 2000·Journal of Cellular Physiology·R N KolesnickA Alonso
Aug 9, 2001·The European Respiratory Journal·J CortijoE J Morcillo
Aug 18, 2001·American Journal of Respiratory Cell and Molecular Biology·T D OuryB J Day
Aug 7, 2002·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohamed H DabaHassan A El-Kashef
Nov 21, 2002·Pharmacology & Therapeutics·Heike SchäckeKhusru Asadullah
Mar 26, 2003·European Journal of Pharmacology·Yuh-Chiang ShenChieh-Fu Chen
Jul 16, 2004·The Journal of Clinical Investigation·Jeffrey D Browning, Jay D Horton
Dec 28, 2004·Journal of Ethnopharmacology·Li-kun GongJin Ren
May 17, 2005·Expert Review of Proteomics·Xianlin Han, Richard W Gross
Oct 18, 2005·Chemistry and Physics of Lipids·Michael SchlameIvan Haller
Jan 18, 2006·Journal of the American Society for Mass Spectrometry·Xianlin HanRichard W Gross
Aug 11, 2006·American Journal of Physiology. Cell Physiology·Adam J Chicco, Genevieve C Sparagna
Aug 22, 2006·Biochimica Et Biophysica Acta·Maria L GasparSusan A Henry
Sep 16, 2006·FEBS Letters·Michael Schlame, Mindong Ren
Feb 13, 2007·Apoptosis : an International Journal on Programmed Cell Death·François Gonzalvez, Eyal Gottlieb
Oct 16, 2007·The International Journal of Biochemistry & Cell Biology·Antje MoellerMartin Kolb
Jan 15, 2008·Cellular Signalling·Kazuyuki KitataniYusuf A Hannun
Jan 25, 2008·Nature Reviews. Molecular Cell Biology·Gerrit van MeerGerald W Feigenson
Jul 2, 2011·Lancet·Talmadge E KingMoisés Selman

❮ Previous
Next ❯

Citations

Dec 26, 2015·Progress in Lipid Research·Miao WangXianlin Han
Jul 28, 2016·BBA Clinical·Qianghua HuVahid Afshar-Kharghan
Oct 1, 2020·Mass Spectrometry Reviews·Changfeng HuXianlin Han
May 11, 2017·American Journal of Respiratory Cell and Molecular Biology·Alan N HuntMary Jane Thomassen
Oct 8, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Hak-Su KimJin Woo Song
Jun 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Shan-Shan LeiSu-Hong Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Vera IvanovaTamara Minko
Igaku to seibutsugaku. Medicine and biology
T OkamotoT Tanaka
© 2021 Meta ULC. All rights reserved