Lipids and cardiac arrhythmia
In any discussion of lipids and heart disease it is beneficial from the outset to recognise that at least three different pathological processes may be involved. The first of these is atherosclerosis which involves the deposition of "fat" in the coronary vessels, another is thrombogenesis which describes the formation of blood clots in the coronary vessels, and the third is arrhythmia which refers to disorders in the beating of the heart which may become sufficiently serious to cause sudden cardiac death (SCD). Also it is this disturbance in the rhythmic beating of the heart which is responsible for much of the mortality from 'heart attacks' which occur 'outside-of-hospital' in societies like U.S.A., U.K. and Australia. It is this latter condition of cardiac arrhythmia which is the major concern of this review. Because it is often difficult to differentiate the role of lipids in 'heart disease' in man, it has frequently been assumed that all dietary fatty acids have similar effects on the different processes involved, and many unwarranted generalisations have been made which have led to conflicts of opinion amongst physicians and confusion in the lay public. From the animal studies discussed in this review, it is apparent that ...Continue Reading
Pharmacokinetic differences between single and multiple oral dosing with the guidance for beta-adrenoceptor blockade assessment
The influence of dietary mackerel oil on the condition of organs and on blood lipid composition in the young growing pig
Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation
Effects of dietary fats on the coronary flow rate and the left ventricular function of the isolated rat heart
Comparison of lipid status in the hearts of piglets and rats on short term feeding of marine oils and rapeseed oils
Actions of prostaglandin precursors and other unsaturated fatty acids on conduction time and refractory period in the cat heart in situ
The influence of unsaturated fatty acids on prostaglandin-release in isolated perfused guinea-pig hearts
Effect of essential and nonessential fatty acids in complex mixture on fatty acid composition of liver lipids
Failure of dietary erucic acid to impair oxidative capacity or APT production of rat heart mitochondria isolated under controlled conditions
Prostaglandin release and mechanical perfromance in the isolated rabbit heart during induced changes in the internal environment
Differences in fatty acid composition of various tissues of the marmoset monkey (Callithrix jacchus) after different lipid supplemented diets
Dietary fat modulation of left ventricular ejection fraction in the marmoset due to enhanced filling
Effects of dietary fish oil on myocardial ischemic/reperfusion injury of Wistar Kyoto and stroke-prone spontaneously hypertensive rats
Ischemic myocardial damage in spontaneously hypertensive rats (SHR) is enhanced after long-term feeding of an alpha-linolenic acid enriched diet
Differences between in vivo and in vitro production of eicosanoids following long-term dietary fish oil supplementation in the rat
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial
Drug therapy for ventricular tachyarrhythmias: how many electropharmacologic trials are appropriate?
Changes in myocardial eicosanoid production following long-term dietary lipid supplementation in rats
The comparative effects of dietary alpha-linolenic acid and fish oil on 4- and 5-series leukotriene formation in vivo
Efficacy and safety of quinidine therapy for maintenance of sinus rhythm after cardioversion. A meta-analysis of randomized control trials
Reversal of the arrhythmogenic effects of long-term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids
Arachidonic acid cascade and the generation of ischemia- and reperfusion-induced ventricular arrhythmias
Dietary lipid modulation of myocardial beta-adrenergic mechanisms, Ca2+-dependent automaticity, and arrhythmogenesis in the marmoset
Fall in coronary heart disease mortality in U.S.A. and Australia due to sudden death: evidence for the role of polyunsaturated fat
Long-chain n-3 polyunsaturated fatty acid incorporation into human atrium following fish oil supplementation
Fish consumption, n-3 fatty acids in cell membranes, and heart rate variability in survivors of myocardial infarction with left ventricular dysfunction
Differential effects of various eicosanoids on the production or prevention of arrhythmias in cultured neonatal rat cardiac myocytes
N-3 polyunsaturated fatty acid supplementation alters inositol phosphate metabolism and protein kinase C activity in adult porcine cardiac myocytes
The role of omega-3 polyunsaturated fatty acid-enriched diets in the prevention of ventricular fibrillation
Ecological study of reasons for sharp decline in mortality from ischaemic heart disease in Poland since 1991
Specific modifications of phosphatidylinositol and nonesterified fatty acid fractions in cultured porcine cardiomyocytes supplemented with n-3 polyunsaturated fatty acids
Membrane basis for fish oil effects on the heart: linking natural hibernators to prevention of human sudden cardiac death
TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT
Lipid metabolites and their differential pro-arrhythmic profiles: of importance in the development of a new anti-arrhythmic pharmacology
Common lipid features of lethal ventricular tarchyarrhythmias (LVTAs) induced by myocardial infarction and myocardial ion channel diseases
Heart rate variability and fatty acid content of blood cell membranes: a dose-response study with n-3 fatty acids
Prevention of cardiac arrhythmia by dietary (n-3) polyunsaturated fatty acids and their mechanism of action
Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat
Anti-Arrhythmic Drug Therapies
Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.
Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.
Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.
Blood Clotting Disorders
Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.
Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.