Lipids: chemical tools for their synthesis, modification, and analysis.

Chemical Society Reviews
Judith FloresNeal K Devaraj

Abstract

Lipids remain one of the most enigmatic classes of biological molecules. Whereas lipids are well known to form basic units of membrane structure and energy storage, deciphering the exact roles and biological interactions of distinct lipid species has proven elusive. How these building blocks are synthesized, trafficked, and stored are also questions that require closer inspection. This tutorial review covers recent advances on the preparation, derivatization, and analysis of lipids. In particular, we describe several chemical approaches that form part of a powerful toolbox for controlling and characterizing lipid structure. We believe these tools will be helpful in numerous applications, including the study of lipid-protein interactions and the development of novel drug delivery systems.

References

Aug 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yoonjung KhoYingming Zhao
Feb 7, 2007·Chembiochem : a European Journal of Chemical Biology·Uyen T T NguyenHerbert Waldmann
Jan 8, 2008·Angewandte Chemie·Helmut H ZepikTakashi Ishikawa
Jan 16, 2009·Angewandte Chemie·Anne B Neef, Carsten Schultz
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Cindy Y JaoAdrian Salic
Jan 14, 2012·Journal of the American Chemical Society·Itay Budin, Neal K Devaraj
Jan 27, 2012·Journal of Medicinal Chemistry·Bhupender S ChhikaraKeykavous Parang
Jun 15, 2012·Angewandte Chemie·Jun YangNeal K Devaraj
Dec 3, 2013·Nature Chemical Biology·Xinxin Gao, Rami N Hannoush
Jan 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrei MaksimenkoPatrick Couvreur
Aug 2, 2014·Angewandte Chemie·Roman S ErdmannAlanna Schepartz
Oct 28, 2014·Angewandte Chemie·Roberto J BreaNeal K Devaraj
Jan 15, 2015·Chembiochem : a European Journal of Chemical Biology·Cindy Y JaoAdrian Salic
May 23, 2015·Nature Communications·James Allen FrankDirk Trauner
Jun 24, 2015·Proceedings of the National Academy of Sciences of the United States of America·Michael D HardyNeal K Devaraj
Jul 22, 2016·Proceedings of the National Academy of Sciences of the United States of America·Roberto J BreaNeal K Devaraj
Sep 15, 2016·Journal of the American Chemical Society·James Allen FrankDirk Trauner
Sep 17, 2016·Angewandte Chemie·Timothy W Bumpus, Jeremy M Baskin
Feb 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Doris HöglingerCarsten Schultz
Mar 7, 2017·Journal of the American Chemical Society·Roberto J BreaNeal K Devaraj
Jun 20, 2017·Nature Communications·Feng XiongJing Zhao
Sep 21, 2017·ACS Chemical Biology·Kenneth M LumBenjamin F Cravatt
Oct 6, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Takafumi EnomotoNeal K Devaraj
Nov 7, 2017·ACS Central Science·Timothy W Bumpus, Jeremy M Baskin
Dec 3, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yihui ShenWei Min
Mar 27, 2018·Journal of Proteome Research·Emmanuelle ThinonHoward C Hang
May 8, 2018·Analytical and Bioanalytical Chemistry·Melissa FrickCarla Schmidt
Jun 12, 2018·Journal of the American Chemical Society·Andrés SeoaneNeal K Devaraj
Jul 4, 2018·Proceedings of the National Academy of Sciences of the United States of America·Andrew K Rudd, Neal K Devaraj
Nov 27, 2018·Trends in Biochemical Sciences·Timothy W Bumpus, Jeremy M Baskin
Dec 6, 2018·Journal of the American Chemical Society·Andrew K RuddNeal K Devaraj
Apr 7, 2019·Chemistry and Physics of Lipids·Melissa Frick, Carla Schmidt
Apr 20, 2019·Chemistry and Physics of Lipids·Muneyuki MatsuoTadashi Sugawara
May 1, 2019·Nature Chemical Biology·Johannes MorsteinDirk Trauner
Jul 18, 2019·Proceedings of the National Academy of Sciences of the United States of America·Dongjun LiangJeremy M Baskin
Jul 19, 2019·Journal of the American Chemical Society·Cassandra E CallmannNathan C Gianneschi
Aug 23, 2019·ACS Chemical Biology·Nicole A SpiegelmanHening Lin
Jan 31, 2020·The Journal of Cell Biology·Reika Tei, Jeremy M Baskin

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Citations

Mar 5, 2021·Chemical Society Reviews·Andrea PannwitzSylvestre Bonnet
Apr 9, 2021·Journal of the American Chemical Society·Dahye Kang, Justin Kim
Dec 15, 2020·Journal of Medicinal Chemistry·Gautam KumarShobhna Kapoor
May 13, 2021·Journal of the American Chemical Society·Satyam KhanalNeal K Devaraj
May 22, 2021·Angewandte Chemie·Dahye KangJustin Kim
Jul 26, 2021·Current Opinion in Chemical Biology·Reika Tei, Jeremy M Baskin
Oct 21, 2020·Journal of Agricultural and Food Chemistry·Jianghua ZhangBeiwei Zhu
Oct 21, 2021·ACS Chemical Biology·Anna Kataki-AnastasakouEllen M Sletten

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Methods Mentioned

BETA
Raman spectroscopy
Fluorescence microscopy
lipidation
Fluorescence imaging
chemical modification
Raman
FRET
acylation
GTPases
xenograft

Software Mentioned

RT
ProCho
INSYRT
IMPACT

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