Lipids implicated in the journey of a secretory granule: from biogenesis to fusion

Journal of Neurochemistry
Emeline TanguyNicolas Vitale

Abstract

The regulated secretory pathway begins with the formation of secretory granules by budding from the Golgi apparatus and ends by their fusion with the plasma membrane leading to the release of their content into the extracellular space, generally following a rise in cytosolic calcium. Generation of these membrane-bound transport carriers can be classified into three steps: (i) cargo sorting that segregates the cargo from resident proteins of the Golgi apparatus, (ii) membrane budding that encloses the cargo and depends on the creation of appropriate membrane curvature, and (iii) membrane fission events allowing the nascent carrier to separate from the donor membrane. These secretory vesicles then mature as they are actively transported along microtubules toward the cortical actin network at the cell periphery. The final stage known as regulated exocytosis involves the docking and the priming of the mature granules, necessary for merging of vesicular and plasma membranes, and the subsequent partial or total release of the secretory vesicle content. Here, we review the latest evidence detailing the functional roles played by lipids during secretory granule biogenesis, recruitment, and exocytosis steps. In this review, we highlight...Continue Reading

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Citations

Jan 1, 2020·IUBMB Life·Fanny LaguerreMaité Montero-Hadjadje
Feb 15, 2020·Biology of Reproduction·Eleanore V O'NeilThomas E Spencer
Oct 5, 2017·Scientific Reports·Joanna L RichensPaul O'Shea
Sep 30, 2017·Biology of the Cell·Stéphane Gasman, Nicolas Vitale
Feb 8, 2019·Frontiers in Cellular Neuroscience·Emeline TanguyNicolas Vitale
Apr 1, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ophélie CarmonMaité Montero-Hadjadje
Sep 13, 2020·Cells·Marion GabelSylvette Chasserot-Golaz
Nov 5, 2020·Cellular and Molecular Life Sciences : CMLS·Muhmmad Omar-Hmeadi, Olof Idevall-Hagren
Dec 9, 2020·Advances in Biological Regulation·Emeline TanguyNicolas Vitale
Sep 29, 2018·Advances in Biological Regulation·Hervé Moine, Nicolas Vitale
Aug 7, 2021·Biomedicines·Tong LinSophia Schedin-Weiss

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