Lipids in ultraviolet radiation-induced immune modulation.

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Benita C Y Tse, Scott Byrne

Abstract

Ultraviolet (UV) radiation-mediated immune suppression is a key mechanism conferring both detrimental and beneficial impacts of sun exposure on human health. Suppression of anti-tumour responses promotes the development and progression of UV-induced skin cancers. In contrast, suppression of dysregulated immune responses facilitate the therapeutic success of phototherapy treatment for skin disorders and is postulated to be responsible for UV protection from autoimmune diseases. While some of the molecular and cellular mechanisms underlying UV-suppression of the immune system are known, a relatively unexplored area is immunomodulatory lipids. Cutaneous UV exposure changes lipids both locally in the skin, increasing platelet-activating factor (PAF) production and decreasing free triglyceride levels, and systemically reducing adipose tissue mass. There is growing recognition that bioactive lipids and lipid metabolism directly affect immune cell phenotype and function. Manipulation of immunomodulatory lipid pathways are effective strategies in modifying systemic immune responses. Indeed, the PAF pathway is a key initiator of UV-induced immune suppression and antagonism of PAF-receptors restores immune function and reduces skin cance...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M L KripkeD B Yarosh
Mar 1, 1989·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·C ColasG Tchobroutsky
Nov 1, 1988·Photochemistry and Photobiology·V E ReeveC H Gallagher
Nov 1, 1984·Photochemistry and Photobiology·M M Mathews-Roth, N I Krinsky
Mar 23, 2001·Nature Immunology·A M MoodycliffeS E Ullrich
Jun 22, 2001·Radiation Research·R M Moison, G M Beijersbergen Van Henegouwen
Jan 24, 2002·The Journal of Experimental Medicine·Jeffrey P WalterscheidDat X Nghiem
Jan 8, 2004·The Journal of Investigative Dermatology·Peter WolfHelmut Kerl
Jul 30, 2005·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Johanna M KuchelGary M Halliday
Aug 6, 2005·Photochemistry and Photobiology·Scott N ByrneGary M Halliday
Jun 20, 2006·Biochemical and Biophysical Research Communications·Min Jeong SongJae Bum Kim
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yumi MatsumuraStephen E Ullrich
Dec 5, 2006·Nature Medicine·Karin LoserStefan Beissert
Jan 11, 2007·Biochemical and Biophysical Research Communications·Takayoshi SuganamiYoshihiro Ogawa
Feb 23, 2008·The American Journal of Pathology·Sabita RanaGary Mark Halliday
Feb 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akira MaedaAgatha Schwarz
Mar 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Scott N ByrneStephen E Ullrich
Apr 25, 2008·Journal of the American Academy of Dermatology·Darrell S Rigel
May 17, 2008·Cancer Research·Coimbatore S SreevidyaStephen E Ullrich
Jun 6, 2009·Nature·Erika L PearceYongwon Choi
Nov 26, 2009·World Journal of Gastroenterology : WJG·Mary Ann CoxChung-Her Jenh
Dec 18, 2009·Nature·Erin D PleasanceMichael R Stratton
Sep 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Atsushi FukunagaStephen E Ullrich
Jan 18, 2011·Archives of Biochemistry and Biophysics·Wesley LewisNabiha Yusuf
Feb 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ryan D MichalekJeffrey C Rathmell
May 13, 2011·The Journal of Investigative Dermatology·Eun Ju KimJin Ho Chung
Dec 31, 2011·Immunity·Gerritje J W van der WindtErika L Pearce
Jun 15, 2012·The Journal of Investigative Dermatology·Allan JensenSusanne K Kjær
Jul 19, 2013·American Journal of Epidemiology·Shih-Wen LinChristian C Abnet
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Gerritje J W van der WindtErika L Pearce
Nov 15, 2013·The Journal of Investigative Dermatology·Seri N E SarchioScott N Byrne
May 6, 2014·The Journal of Nutritional Biochemistry·Eve DraperChristine E Loscher
Jul 23, 2014·The Journal of Investigative Dermatology·Matheus FerraciniJeffrey B Travers

❮ Previous
Next ❯

Citations

Mar 17, 2021·Acta Physiologica·Cameron R Moattari, Richard D Granstein
Mar 16, 2021·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·R E NealeM Zhu
Apr 3, 2021·Frontiers in Endocrinology·Jeffrey B TraversRavi P Sahu
Apr 9, 2021·The Journal of Clinical Investigation·Langni LiuJeffrey B Travers
Jul 30, 2021·Photochemistry and Photobiology·Cameron L McGloneJeffrey B Travers
Sep 26, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benita C Y TseScott N Byrne

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The Journal of Investigative Dermatology. Symposium Proceedings
Chikako NishigoriMargaret L Kripke
Journal of Dermatological Science
Stephen E Ullrich, D A Schmitt
Frontiers in Bioscience : a Journal and Virtual Library
Stephen E Ullrich
© 2022 Meta ULC. All rights reserved