Lipids of plasma, retina, and retinal pigment epithelium in Swedish briard dogs with a slowly progressive retinal dystrophy

Experimental Eye Research
R E AndersonS E Nilsson

Abstract

Reduced blood levels of long chain polyunsaturated fatty acids have been reported in humans and animals with inherited retinal degenerations. The lipid and fatty acid compositions of plasma, retina, and retinal pigment epithelium of the Swedish Briard dog, which has a very slowly progressive retinal dystrophy that is inherited in an autosomal recessive manner were analysed. The lipid class composition of the pigment epithelium was not different between affected and normal dogs; however, significant differences were found between the retinas of the two groups. Affected dogs had relatively more phosphatidylethanolamine and phosphatidylinositol and less phosphatidylcholine than normal dogs. There was no difference in the fatty acid compositions of plasma and retinal pigment epithelium between affected and normal dogs. However, the retinas of affected dogs had significantly lower levels of 22:5n-3 and 22:6n-3 and higher levels of 18:2n-6, 20:4n-6, and 22:5n-6. The total n-3 fatty acid content was significantly lower in affected retinas (P < 0.001), whereas the content of n-6 fatty acids was significantly higher in affected retinas (P < 0.001). These studies provide evidence for yet another animal model of inherited retinal degenera...Continue Reading

Citations

Oct 16, 2009·Journal of Lipid Research·Norma M GiustoMónica G Ilincheta de Boschero
Mar 26, 2011·Progress in Lipid Research·Beata JastrzebskaKrzysztof Palczewski
Jun 22, 2007·The Veterinary Journal·G L ZapataA M Terrasa
Jul 25, 2009·Journal of Neurochemistry·Stefanie EbertThomas Langmann
Dec 6, 2014·Progress in Retinal and Eye Research·Marcus KarlstetterThomas Langmann
Nov 4, 2000·The Journal of Biological Chemistry·E HesselK P Hofmann
May 22, 1998·Neurochemistry International·J Y Chang, L Z Liu

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