Lipoblastic nerve sheath tumors: report of a distinctive variant of neural soft tissue neoplasm with adipocytic differentiation

The American Journal of Surgical Pathology
Jose Antonio PlazaSaul Suster

Abstract

Benign nerve sheath tumors of soft tissue can occasionally adopt unusual or unfamiliar morphologic appearances that may introduce difficulties for diagnosis, such as multinucleation, bizarre nuclei, intranuclear vacuoles, and other degenerative changes. Tumor cells adopting a signet-ring or lipoblast-like configuration, however, are mostly associated with epithelial malignancies, liposarcoma and melanoma, and have been only rarely observed in spindle cell tumors of soft tissue. We report 5 cases of benign nerve sheath neoplasms that displayed prominent signet-ring cells with lipoblast-like features. The cases presented as solitary soft tissue masses in the groin, thigh, retroperitoneum, and shoulder in 4 men and 1 woman between the ages of 31 to 57 years. Four tumors predominantly showed features of schwannoma and one of neurofibroma; however, intimately admixed with the spindle cell population, there were also numerous scattered mature adipocytes as well as lipoblast-like cells displaying a signet-ring cell appearance. Immunohistochemical studies showed strong S-100 protein positivity in the spindle cells as well as in the signet-ring lipoblast-like cells and the mature adipocytes. The signet-ring cells were negative for mucin...Continue Reading

Citations

Dec 11, 2007·Diagnostic Pathology·Sameer Singh Shaktawat, Dariusz Golka
Mar 8, 2008·Annals of Diagnostic Pathology·Gary TozbikianSaul Suster
Aug 19, 2010·Veterinary Pathology·S SchönigerB A Summers
Dec 12, 2013·International Journal of Surgical Pathology·Tao WangUma N M Rao
Aug 30, 2011·International Journal of Surgical Pathology·Faysal A FeddaFouad I Boulos
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Justin M M Cates, Cheryl M Coffin
Dec 20, 2007·Applied Immunohistochemistry & Molecular Morphology : AIMM·Jose Antonio PlazaDelia Perez-Montiel
Feb 9, 2018·Journal of Clinical Pathology·Aoife J McCarthyRunjan Chetty
Aug 30, 2008·Journal of Cutaneous Pathology·Davor TomasBozo Kruslin
Jun 27, 2008·The American Journal of Surgical Pathology·Thomas M Ulbright, Robert H Young
May 23, 2008·The American Journal of Dermatopathology·Alessandra C Macarenco, Ricardo S Macarenco

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