Lipocalin 2 expression is associated with aggressive features of endometrial cancer.

BMC Cancer
Monica MannelqvistLars A Akslen

Abstract

Increased expression of lipocalin 2 (LCN2) has been observed in several cancers. The aim of the present study was to investigate LCN2 in endometrial cancer in relation to clinico-pathologic phenotype, angiogenesis, markers of epithelial-mesenchymal transition (EMT), and patient survival. Immunohistochemical staining was performed using a human LCN2 antibody on a population-based series of endometrial cancer patients collected in Hordaland County (Norway) during 1981-1990 (n = 256). Patients were followed from the time of primary surgery until death or last follow-up in 2007. The median follow-up time for survivors was 17 years. Gene expression data from a prospectively collected endometrial cancer series (n = 76) and a publicly available endometrial cancer series (n = 111) was used for gene correlation studies. Expression of LCN2 protein, found in 49% of the cases, was associated with non-endometrioid histologic type (p = 0.001), nuclear grade 3 (p = 0.001), >50% solid tumor growth (p = 0.001), ER and PR negativity (p = 0.028 and 0.006), and positive EZH2 expression (p < 0.001). LCN2 expression was significantly associated with expression of VEGF-A (p = 0.021), although not with other angiogenesis markers examined (vascular pro...Continue Reading

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Citations

Jun 19, 2012·Cell Biochemistry and Biophysics·Ming-Hsien ChienYi-Hsien Hsieh
Jan 22, 2013·Journal of Molecular Endocrinology·Xinwang ChenJihong Kang
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Mar 5, 2019·Cancer Biomarkers : Section a of Disease Markers·Aneta Cymbaluk-PłoskaJanusz Menkiszak
Jan 7, 2020·Cellular and Molecular Life Sciences : CMLS·Sayan GhoshDebasish Sinha
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Jun 22, 2021·Frontiers in Cell and Developmental Biology·Sabina SanegreRosa Noguera
Aug 28, 2021·International Journal of Molecular Sciences·Ginette S Santiago-SánchezPablo E Vivas-Mejía

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BETA
E-MTAB-1007
GSE2109

Software Mentioned

PANTHER
Aceview
PASW

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