Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior

Psychopharmacology
Elisabeth G VichayaRobert Dantzer

Abstract

While the relationship between inflammation and depression is well-established, the molecular mechanisms mediating this relationship remain unclear. RNA sequencing analysis comparing brains of vehicle- and lipopolysaccharide-treated mice revealed LCN2 among the most dysregulated genes. As LCN2 is known to be an important regulator of the immune response to bacterial infection, we investigated its role in the behavioral response to lipopolysaccharide. To explore the role of LCN2 in modulating behavior following lipopolysaccharide administration using wild type (WT) and lcn2-/- mice. Using a within-subjects design, mice were treated with 0.33 mg/kg liposaccharide (LPS) and vehicle. Primary outcome measures included body weight, food consumption, voluntary wheel running, sucrose preference, and the tail suspension test. To evaluate the inflammatory response, 1 week later, mice were re-administered either vehicle or LPS and terminated at 6 h. While lcn2-/- mice had increased baseline food consumption and body weight, they showed a pattern of reduced food consumption and weight loss similar to WT mice in response to LPS. WT and lcn2-/- mice both recovered voluntary activity on the fourth day following LPS. LPS induced equivalent red...Continue Reading

References

Sep 15, 1994·Biological Psychiatry·F BiverF Lotstra
Apr 15, 1999·Annual Review of Neuroscience·C L Colby, M E Goldberg
Aug 12, 1999·Advances in Experimental Medicine and Biology·A J DunnT Ando
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·R DantzerK W Kelley
May 16, 2001·Archives of General Psychiatry·A ReichenbergT Pollmächer
May 11, 2007·Experimental and Molecular Pathology·Vasanthi R SunilDebra L Laskin
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Feb 23, 2008·Molecular Endocrinology·Jinhui ZhangXiaoli Chen
May 15, 2008·Journal of Neuroinflammation·Christopher J HenryJonathan P Godbout
Dec 18, 2009·Biological Psychiatry·Yekta DowlatiKrista L Lanctôt
Aug 20, 2010·Biological Psychiatry·Naomi I EisenbergerMichael R Irwin
Mar 24, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Petrus J W NaudéUlrich L M Eisel
Dec 5, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Eunha JangKyoungho Suk
Mar 8, 2013·Depression and Anxiety·Andrew H MillerJennifer C Felger
Jul 23, 2013·Journal of Affective Disorders·Vyara ValkanovaCharlotte L Allan
Oct 4, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eunha JangKyoungho Suk
Jan 7, 2014·The Journal of Biological Chemistry·Peng ZhaoJacqueline M Stephens
Jan 9, 2014·Journal of the Neurological Sciences·Silmar TeixeiraJulio Guilherme Silva
Jan 11, 2014·Brain, Behavior, and Immunity·Radboud M MarijnissenRichard C Oude Voshaar
Jan 11, 2014·Brain, Behavior, and Immunity·Petrus J W NaudéRegien G Schoemaker
Jul 15, 2015·Peptides·J T DwarkasingK van Norren
Jul 28, 2015·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Petrus J W NaudéRegien G Schoemaker
Mar 26, 2016·Brain, Behavior, and Immunity·Paula M C MommersteegJohan Denollet
Jan 11, 2017·Molecular Psychiatry·S S KangJ D Fryer
Mar 9, 2017·Nature·Ioanna MosialouStavroula Kousteni
Mar 9, 2017·Nature·Richard D Palmiter
Jun 24, 2017·Neuroscience·Hemanth MohanChristiaan P J de Kock

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Citations

Apr 19, 2020·Current Opinion in Neurology·Roald Omdal
Mar 10, 2020·Neuroscience and Biobehavioral Reviews·Rafael González-CanoEnrique J Cobos
Apr 8, 2021·Nature Communications·Brennan OlsonDaniel L Marks
Jul 11, 2021·Brain, Behavior, and Immunity·Brennan OlsonDaniel L Marks
Jul 30, 2021·Ageing Research Reviews·Doortje W DekensPetrus J W Naudé

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