Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides

Journal of Neurochemistry
Ikuko MohriKinuko Suzuki

Abstract

Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is a dually functional protein, acting both as a PGD2-synthesizing enzyme and as an extracellular transporter of various lipophilic small molecules. L-PGDS is expressed in oligodendrocytes (OLs) in the central nervous system and is up-regulated in OLs of the twitcher mouse, a model of globoid cell leukodystrophy (Krabbe's disease). We investigated whether up-regulation of L-PGDS is either unique to Krabbe's disease or is a more generalized phenomenon in lysosomal storage disorders (LSDs), using LSD mouse models of Tay-Sachs disease, Sandhoff disease, GM1 gangliosidosis and Niemann-Pick type C1 disease. Quantitative RT-PCR revealed that L-PGDS mRNA was up-regulated in the brains of all these mouse models. In addition, strong L-PGDS immunoreactivity was observed in OLs, but not in either astrocytes or microglia in these models. Thus, up-regulation of L-PGDS appears to be a common response of OLs in LSDs. Moreover, surface plasmon resonance analyses revealed that L-PGDS binds GM1 and GM2 gangliosides, accumulated in neurons in the course of LSD, with high affinities (KD = 65 and 210 nm, respectively). This suggests that L-PGDS may play a role in scavenging harmful lipophilic su...Continue Reading

References

Feb 1, 1988·Archives of Biochemistry and Biophysics·M UjiharaO Hayaishi
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Sep 1, 1980·Brain : a Journal of Neurology·L W DuchenF Teixeira
Sep 15, 1994·Biochemical and Biophysical Research Communications·K WatanabeO Hayaishi
Jan 1, 1993·Acta Neuropathologica·Y HigashiK Suzuki
Oct 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·Y UradeO Hayaishi
Oct 15, 1995·Microscopy Research and Technique·K Suzuki, M Taniike
Jan 12, 1996·Science·J E SherinC B Saper
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·T ScammellO Hayaishi
Jan 20, 1999·Proceedings of the National Academy of Sciences of the United States of America·N EguchiO Hayaishi
Feb 16, 1999·Biochimica Et Biophysica Acta·Y Urade, O Hayaishi
Jun 22, 1999·Journal of Neuropathology and Experimental Neurology·M TaniikeK Suzuki
Feb 11, 2000·Vitamins and Hormones·Y Urade, O Hayaishi
Jun 2, 2000·Molecular Genetics and Metabolism·D A WengerE Costantino-Ceccarini
Feb 24, 2001·Traffic·R E PaganoD L Marks
Feb 15, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Osamu Hayaishi, Yoshihiro Urade
May 23, 2002·Human Molecular Genetics·Rachel MyerowitzRichard L Proia
Jan 30, 2003·Annals of Medicine·Peter T NelsonEhud Lavi
Feb 6, 2004·The Journal of Biological Chemistry·Rosa SalvioliAnna Maria Vaccaro
Jun 26, 2004·Journal of Neuropathology and Experimental Neurology·Shoichi TakikitaKinuko Suzuki
Oct 7, 2004·Biochimica Et Biophysica Acta·Steven U Walkley, Kinuko Suzuki
Jun 23, 2005·The Journal of Biological Chemistry·Louis RagoliaYoshihiro Urade

❮ Previous
Next ❯

Citations

Sep 8, 2010·Modern Rheumatology·Hassan FahmiMohit Kapoor
Sep 29, 2011·Chemical Reviews·William L SmithPer-Johan Jakobsson
Nov 30, 2010·The Journal of Biological Chemistry·Karine MathurinJean-Luc Parent
Dec 20, 2008·Arthritis Research & Therapy·Nadia ZayedHassan Fahmi
Nov 2, 2011·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Shigeru ShimamotoTadayasu Ohkubo
Sep 28, 2014·Gene·Adriana Carol Eleonora Graziano, Venera Cardile
Jan 10, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ayano FukuharaTakashi Inui
Jul 10, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Takashi InuiYoshihiro Urade
Dec 14, 2007·The FEBS Journal·Tsukimi IidaTakashi Inui
Jul 11, 2012·Mediators of Inflammation·Isabel Vieira de Assis LimaAntonio Carlos Pinheiro de Oliveira
Nov 30, 2018·Expert Opinion on Therapeutic Targets·Asheebo RojasRaymond Dingledine
Dec 13, 2007·Journal of Molecular Recognition : JMR·Rebecca L Rich, David G Myszka
Jul 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yangyan ZhouZhi-Jie Liu
Apr 27, 2020·Arthritis & Rheumatology·Mehdi NajarHassan Fahmi
Sep 18, 2016·Journal of Neuroscience Research·Rosanna AvolaVenera Cardile
Apr 15, 2021·Molecular Human Reproduction·Pascal PhilibertBrigitte Boizet-Bonhoure
Aug 28, 2021·International Journal of Molecular Sciences·Natalia A ShnayderRegina F Nasyrova

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.