Lipofuscin as an indicator of oxidative stress and aging

Advances in Experimental Medicine and Biology
R S Sohal, U Brunk

Abstract

There is a considerable body of evidence indicating that oxidative stress is a causal factor both in lipofuscinogenesis as well as in aging. Studies on the effects of pro-oxidants and antioxidants on lipofuscin accumulation in cultured rat cardiac myocytes and human glial cells indicated that pro-oxidants accelerate while antioxidants retard the rate of lipofuscin accumulation. Lipofuscin was measured by microspectrofluorometry; the reliability of this method was independently validated by comparison with electron microscopical morphometry. In vivo studies on hibernating mammals and on insects indicate that rate of lipofuscin is enhanced while life span is shortened by elevation in metabolite rate. The increase in metabolic rate has been shown to enhance the rate of lipid peroxidation, measured as n-pentane exhalation in vivo. Overall, it seems that there is enough evidence at hand to reasonably infer that lipofuscin can be used as a marker of oxidative stress and aging.

Citations

Oct 15, 2013·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Emmanuel P Gilissen, Ludmilla Staneva-Dobrovski
Jul 10, 2019·BMC Complementary and Alternative Medicine·Panthakarn RangsinthTewin Tencomnao
Sep 19, 2007·Journal of Nutritional Science and Vitaminology·Hsin-Ping OuChiun C R Wang
Aug 14, 1999·The Journal of Biological Chemistry·J WassellM Boulton
Aug 17, 2021·Acta Medica Lituanica·Ho Hin Ma, Rasa Liutkevičienė
Mar 7, 1998·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·L H TanH G Hartwig

❮ Previous
Next ❯

Related Concepts

Related Feeds

Batten Disease

Batten Disease is a group of nervous system disorders known as neuronal ceroid lipofuscinosis. This feed focuses on neurobiological and neuropathological aspects of this disease.