Lipofuscin: mechanisms of formation and increase with age

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
A Terman, U T Brunk

Abstract

Lipofuscin (age pigment) is a brown-yellow, electron-dense, autofluorescent material that accumulates progressively over time in lysosomes of postmitotic cells, such as neurons and cardiac myocytes. The exact mechanisms behind this accumulation are still unclear. This review outlines the present knowledge of age pigment formation, and considers possible mechanisms responsible for the increase of lipofuscin with age. Numerous studies indicate that the formation of lipofuscin is due to the oxidative alteration of macromolecules by oxygen-derived free radicals generated in reactions catalyzed by redox-active iron of low molecular weight. Two principal explanations for the increase of lipofuscin with age have been suggested. The first one is based on the notion that lipofuscin is not totally eliminated (either by degradation or exocytosis) even at young age, and, thus, accumulates in postmitotic cells as a function of time. Since oxidative reactions are obligatory for life, they would act as age-independent enhancers of lipofuscin accumulation, as well as of many other manifestations of senescence. The second explanation is that the increase of lipofuscin is an effect of aging, caused by an age-related enhancement of autophagocytos...Continue Reading

References

Jan 1, 1976·Essays in Biochemistry·R T Dean, A J Barrett
Oct 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·A B Novikoff, W Y Shin
Dec 1, 1979·Mechanisms of Ageing and Development·A Z Reznick, D Gershon
Oct 1, 1977·Journal of Molecular and Cellular Cardiology·K WildenthalJ T Dingle
Jun 1, 1992·Journal of Neurochemistry·M Banay-SchwartzA Lajtha
Aug 1, 1992·Experimental Cell Research·B R DiPaoloV J Cristofalo
Feb 15, 1992·Experientia·P O Seglen, P Bohley
Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W Ward, A Richardson
Mar 1, 1991·Mechanisms of Ageing and Development·G O IvyK Kitani
Mar 1, 1991·Aging : Clinical and Experimental Research·A Del RosoE Bergamini
Sep 1, 1990·Cell Biology International Reports·J P SchellensA J Meijer
Feb 1, 1990·Journal of Electron Microscopy Technique·D L Schmucker
Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·P ConstantinidesD McLaury
Jan 1, 1988·American Journal of Medical Genetics. Supplement·L S WolfeJ Palo
Dec 1, 1988·Mechanisms of Ageing and Development·M R MarzabadiU T Brunk
Nov 1, 1987·Chemical & Pharmaceutical Bulletin·K KikugawaK Sakurai
Mar 1, 1987·The Journal of Investigative Dermatology·R M LavkerG Dong
Jun 1, 1987·Mechanisms of Ageing and Development·M L KatzW G Robison
Jul 1, 1986·Cell Biology International Reports·E J de WaalJ James
Jun 1, 1986·Mechanisms of Ageing and Development·A HervonenS I Rapoport
Nov 1, 1970·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A Brun, U Brunk
Jun 22, 1965·Biochimica Et Biophysica Acta·D D Hendley, B L Strehler
Jun 1, 1972·Journal of Ultrastructure Research·D BrandesS Barnard
Jan 1, 1966·Annual Review of Physiology·C De Duve, R Wattiaux
Dec 1, 1969·Journal of Ultrastructure Research·R J HendyP Grasso
Jun 1, 1970·The Journal of Experimental Medicine·E RobbinsH Eagle
Apr 1, 1970·Experimental and Molecular Pathology·R Abraham, R J Hendy
Jan 1, 1968·Journal of Gerontology·W ReichelB L Strehler
Apr 1, 1968·Journal of Gerontology·J F Munnell, R Getty
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·L MarzellaH Glaumann

❮ Previous
Next ❯

Citations

Jun 7, 2012·Cellular and Molecular Life Sciences : CMLS·Kanchan PhadwalAnna Katharina Simon
Jun 21, 2006·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·T Ravi KiranS Asha Devi
Feb 9, 2008·Histochemistry and Cell Biology·Tino KurzUlf T Brunk
Jun 22, 2012·Medical Molecular Morphology·Reidar Alexander VigenChun-Mei Zhao
Jan 4, 2008·Heart Failure Reviews·Eloisa ArbustiniJagat Narula
Dec 15, 2005·Heart, Lung & Circulation·Alexei Terman, Ulf T Brunk
Apr 18, 2000·Experimental Gerontology·A M Cuervo, J F Dice
Jun 28, 2002·Experimental Gerontology·Kathryn M Jervis, Bernard Robaire
Jul 12, 2003·Experimental Gerontology·Shuji KishiStephanie B Tsai
Aug 18, 2000·Free Radical Biology & Medicine·J W Baynes, S R Thorpe
Dec 19, 2000·Free Radical Biology & Medicine·F S FacchiniR A Stoohs
Sep 5, 2002·Free Radical Biology & Medicine·Ulf T Brunk, Alexei Terman
Oct 3, 2003·Ageing Research Reviews·Pamela A SzwedaLuke I Szweda
May 19, 2011·Nature Reviews. Neuroscience·Timothy J CollierJeffrey H Kordower
Jun 7, 2000·Neuropathology and Applied Neurobiology·P V BelichenkoJ R Fraser
Aug 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Horng-Dar WangSeymour Benzer
Sep 27, 2000·Proceedings of the National Academy of Sciences of the United States of America·E C GoodwinE S Hwang
Jun 4, 2002·DNA and Cell Biology·Aubrey D N J De Grey
Feb 21, 2006·Antioxidants & Redox Signaling·Roberta KiffinAna Maria Cuervo
Oct 13, 2006·Antioxidants & Redox Signaling·Susan E Browne, M Flint Beal
Sep 4, 2008·Antioxidants & Redox Signaling·Violetta N PivtoraikoJohn J Shacka
Dec 31, 2009·Antioxidants & Redox Signaling·Tino KurzUlf T Brunk
Dec 28, 2007·Rejuvenation Research·Tino Kurz
Aug 31, 2002·Nucleic Acids Research·Natalya BodyakAnny Usheva
Jan 16, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·Hans K Biesalski
Aug 24, 1999·Pigment Cell Research·U Schraermeyer, K Heimann
Dec 18, 2002·Annals of the New York Academy of Sciences·Alexei Terman, Sara Sandberg
Sep 4, 2008·Photochemistry and Photobiology·Prasun MukherjeeJacob W Petrich
Aug 7, 2009·Photochemistry and Photobiology·Ramkrishna AdhikaryJacob W Petrich
Nov 13, 2008·PloS One·Fatemeh HeidaryReza Gharebaghi
Jul 30, 2010·Clinical Ophthalmology·Giuseppe QuerquesEric H Souied
Jan 22, 2013·Journal of Proteomics·Annika HöhnTilman Grune
Oct 22, 2011·Cellular and Molecular Life Sciences : CMLS·Hua ZhaoBrett Garner
May 4, 2005·Ophthalmic Research·Rangaprasad Sarangarajan, Shireesh P Apte
Dec 2, 2015·Journal of Agricultural and Food Chemistry·Ujjal BhattacharjeeJacob W Petrich

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