Lipofuscin response to the "aging-reversal" drug centrophenoxine in rat retinal pigment epithelium and frontal cortex

Journal of Gerontology
M L Katz, W G Robison

Abstract

The effects of centrophenoxine on the lipofuscin contents of the retinal pigment epithelium (RPE) and frontal cortex of the brain were examined in senescent female Fischer rats. Rats (106 weeks old) were injected daily for 11 weeks with centrophenoxine (80 to 120 mg/kg body weight) or saline, and then sacrificed along with untreated 28- and 46-week-old controls. The number of lipofuscin granules seen in the RPE by light microscopy increased by 70% between 28 and 117 weeks of age in control animals. There was a concomitant age-related increase in lipofuscin specific fluorescence in the RPE. Centrophenoxine treatment neither reduced the amount of lipofuscin, nor altered the ultrastructural appearance of lipofuscin granules in the RPE. Between 28 and 117 weeks of age, there was an almost nine-fold increase in the lipofuscin content of the frontal cortex of control animals; centrophenoxine treatment failed to reverse this pigment accumulation.

Citations

Jul 1, 1987·Chemistry and Physics of Lipids·M TsuchidaK Aibara
May 1, 1984·Archives of Gerontology and Geriatrics·C ViticchiL Piantanelli
Mar 1, 1991·Archives of Gerontology and Geriatrics·E A Porta
Nov 1, 1991·Neurobiology of Aging·T J Collier, P D Coleman
Jan 1, 1991·Experimental Gerontology·L BodnerI Hammel
Jan 1, 1993·Progress in Histochemistry and Cytochemistry·D Dayan, M Wolman
Nov 26, 2009·Optometry : Journal of the American Optometric Association·Stuart RicherCarla Thomas
Jan 17, 2012·Neurobiology of Aging·Sylvie Julien, Ulrich Schraermeyer
Jul 1, 1989·The British Journal of Psychiatry : the Journal of Mental Science·J H Dowson

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