Lipohypertrophy in Elderly Insulin-Treated Patients With Type 2 Diabetes.

Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders
Sandro GentileNefrocenter Network and Nyx Start-up Study Group

Abstract

The number of older adults with insulin-treated diabetes mellitus (DM) is steadily increasing worldwide. Errors in the insulin injection technique can lead to skin lipohypertrophy (LH), which is the accumulation of fat cells and fibrin in the subcutaneous tissue. While lipohypertrophic lesions/nodules (LHs) due to incorrect insulin injection techniques are very common, they are often flat and hardly visible and thus require thorough deep palpation examination and ultrasonography (US) for detection. Detection is crucial because such lesions may eventually result in poor diabetes control due to their association with unpredictable insulin release patterns. Skin undergoes fundamental structural changes with aging, possibly increasing the risk for LH. We have therefore investigated the effect of age on the prevalence of LHs and on factors potentially associated with such lesions. A total of 1227 insulin-treated outpatients with type 2 DM (T2DM) referred to our diabetes centers were consecutively enrolled in the study. These patients underwent a thorough clinical and US evaluation of the skin at injection sites, as previously described, with up to 95% concordance betweenthe clinical and US screening techniques. Of these 1227 patient...Continue Reading

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Citations

Mar 10, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sandro GentileUNKNOWN AMD-OSDI Study Group
Mar 20, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sandro GentileUNKNOWN AMD-OSDI Study Group on Injection Technique, Nefrocenter Research and Nyx Start-Up
Aug 13, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sandro GentileUNKNOWN Nefrocenter Research and Nyx Start-Up Study Group

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