Lipolysis and lipases in white adipose tissue - An update

Archives of Endocrinology and Metabolism
Andressa Bolsoni-Lopes, Maria Isabel C Alonso-Vale

Abstract

Lipolysis is defined as the sequential hydrolysis of triacylglycerol (TAG) stored in cell lipid droplets. For many years, it was believed that hormone-sensitive lipase (HSL) and monoacylglycerol lipase (MGL) were the main enzymes catalyzing lipolysis in the white adipose tissue. Since the discovery of adipose triglyceride lipase (ATGL) in 2004, many studies were performed to investigate and characterize the actions of this lipase, as well as of other proteins and possible regulatory mechanisms involved, which reformulated the concept of lipolysis. Novel findings from these studies include the identification of lipolytic products as signaling molecules regulating important metabolic processes in many non-adipose tissues, unveiling a previously underestimated aspect of lipolysis. Thus, we present here an updated review of concepts and regulation of white adipocyte lipolysis with a special emphasis in its role in metabolism homeostasis and as a source of important signaling molecules.

References

Jun 4, 1999·Seminars in Cell & Developmental Biology·C LondosA R Kimmel
Oct 24, 2000·Trends in Endocrinology and Metabolism : TEM·R N Bergman, M Ader
Nov 22, 2001·The Journal of Biological Chemistry·Guenter HaemmerleRudolf Zechner
Sep 21, 2002·Diabetologia·K N Frayn
Oct 3, 2002·Nature Medicine·Hong-Ping GuanMitchell A Lazar
Jul 2, 2003·The Journal of Biological Chemistry·Chun-Li SuConstantine Londos
Nov 5, 2004·Diabetes & Metabolism·V LargeM Beylot
Nov 20, 2004·Science·Robert ZimmermannRudolf Zechner
Aug 30, 2005·Critical Reviews in Biochemistry and Molecular Biology·Tamara C Otto, M Daniel Lane
Oct 22, 2005·EMBO Reports·Elena SmirnovaCatherine L Jackson
May 23, 2006·Metabolism: Clinical and Experimental·Adaliene Versiani Matos FerreiraLeida Maria Botion
Nov 1, 2006·The Journal of Biological Chemistry·Martina SchweigerRobert Zimmermann
Jan 16, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kathy JaworskiHei Sook Sul
Feb 23, 2007·Annual Review of Nutrition·Robin E DuncanHei Sook Sul
Sep 13, 2007·American Journal of Physiology. Endocrinology and Metabolism·Erin E KershawJeffrey S Flier
Jul 11, 2008·The Journal of Biological Chemistry·Robin E DuncanHei Sook Sul
Jan 16, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M Lafontan
May 13, 2009·The Journal of Biological Chemistry·Véronic BezaireDominique Langin
May 26, 2009·Progress in Lipid Research·Max Lafontan, Dominique Langin
Jul 30, 2009·Handbook of Experimental Pharmacology·Arvinder K DhallaLuiz Belardinelli
Aug 25, 2009·The Proceedings of the Nutrition Society·Véronic Bézaire, Dominique Langin
Oct 3, 2009·Journal of Lipid Research·Hideaki MiyoshiAndrew S Greenberg
Dec 8, 2009·Journal of Lipid Research·Gabriele SchoiswohlRobert Zimmermann
Dec 23, 2009·The International Journal of Biochemistry & Cell Biology·Maryam AhmadianHei Sook Sul
Apr 29, 2010·The Journal of Biological Chemistry·Prakash G ChandakDagmar Kratky
Oct 23, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kuok Teong OngDouglas G Mashek
Apr 2, 2011·The Journal of Biological Chemistry·Ulrike TaschlerRobert Zimmermann
Jun 7, 2011·Cell Metabolism·Maryam AhmadianHei Sook Sul
Jun 16, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Girousse, D Langin

❮ Previous
Next ❯

Citations

May 2, 2016·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Jian SunLi-Qiao Chen
Jan 4, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jerzy Bełtowski, Anna Jamroz-Wiśniewska
Jan 7, 2017·Fish Physiology and Biochemistry·Caixia LeiHong Ji
Apr 5, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nicole G BarraDaniel B Hardy
Aug 15, 2018·The British Journal of Nutrition·Giorgio BiasiottoDiego Di Lorenzo
Dec 8, 2017·Analytical and Bioanalytical Chemistry·Xiangpeng Li, Christopher J Easley
Aug 2, 2018·Chemistry : a European Journal·Isabel PeñaJosé L Alonso
May 28, 2019·Nutrition & Metabolism·Seon-Jeong LeeMyung-Sook Choi
Aug 21, 2019·International Journal of Molecular Sciences·Rodolpho R C MonteiroRoberto Fernandez-Lafuente
Aug 26, 2020·International Journal of Molecular Sciences·Noelia Martínez-Sánchez
Apr 22, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M BordicchiaR Sarzani
Mar 30, 2017·Experimental and Therapeutic Medicine·Xiaojuan ZhuGuodong Zheng
Mar 13, 2020·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Yuanxiang LiLulu Chen
Oct 10, 2020·Journal of the Endocrine Society·Alejandra Fernández-CardonaCarlos O Mendivil
Nov 8, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Andreas KrebsKarl Otfried Schwab
Nov 28, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Seon Yeon ChoJae-Young Um
Nov 27, 2020·Frontiers in Cardiovascular Medicine·Alexander E BerezinMichael Lichtenauer
Dec 5, 2020·Oxidative Medicine and Cellular Longevity·Xueying LiuChuangpeng Shen
Mar 25, 2021·Nature Communications·KyeongJin KimUtpal B Pajvani
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andre Mong Jie NgGiang Kien Truc Nguyen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Biochimica Et Biophysica Acta
Robert ZimmermannRudolf Zechner
International Journal of Obesity : Journal of the International Association for the Study of Obesity
A Girousse, Dominique Langin
© 2021 Meta ULC. All rights reserved