Jan 23, 1976

Lipolysis in human adipose tissue (author's transl)

Wiener klinische Wochenschrift
H J LischS Sailer

Abstract

Lipolytic activity was measured under different conditions in isolated fat cells and homogenates of human adipose tissue of the greater omentum. It was demonstrated that lipolysis took place in isolated fat cells at an optimum pH of 7.4 and was markedly stimulated by noradrenaline, but not by blood serum. By contrast lipolysis was significantly stimulated by blood serum, but not by noradrenaline, in homogenates of adipose tissue. Serum-stimulated lipolysis exhibited optimum activity at pH 8 and was inhibited by 1M sodium chloride. It is concluded that lipolytic activity in isolated fat cells can mainly be ascribed to the action of hormone-sensitive lipase, whereas lipolysis in homogenates of adipose tissue in the presence of serum is mostly regulated by lipoprotein lipase.

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Mentioned in this Paper

Fat Pad
Protamine Sulfate (USP)
Greater Omentum
LPL gene
Norepinephrine, (+, -)-Isomer
Fluorides
Norepinephrine
Norepinephrine Measurement
Lipoproteins
Sterol esterase

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