Lipomas of the Oral Cavity: Utility of MDM2 and CDK4 in Avoiding Overdiagnosis as Atypical Lipomatous Tumor

Head and Neck Pathology
Ivan J StojanovSook-Bin Woo

Abstract

Traumatized lipomas with degenerative change may demonstrate histopathologic features that mimic atypical lipomatous tumor (ALT). Previously reported series of ALT involving the oral cavity preceded routine use of MDM2 and CDK4 immunohistochemistry. Our aim is to evaluate MDM2 and CDK4 immunohistochemical expression in adipocytic tumors arising in this site, in conjunction with the histiocytic marker PU.1, to determine whether MDM2 and CDK4 impacts classification. 17 cases originally diagnosed as ALT were retrieved and immunohistochemical studies for MDM2, CDK4 and PU.1 were performed. FISH analysis for MDM2 amplification was performed in select cases. For this study group, the male:female ratio was 9:8 and the median age was 62 (range 41-88). All 17 cases presented as well- or predominantly well-circumscribed proliferations of variably sized, mature adipocytes exhibiting uni- or multi-vacuolation with occasional scalloped nuclei and mild nuclear atypia. Variable amounts of fibrous stroma with focal myxoid change and bland spindle cells were identified in 14/17 cases. Lipoblasts or atypical hyperchromatic stromal cells were not identified in any cases. 14 of 17 cases were negative for MDM2 and CDK4 in tumor cells and 11 of thes...Continue Reading

References

Nov 1, 1994·American Journal of Clinical Pathology·D R LucasM G Rock
Feb 1, 1996·The Journal of Laryngology and Otology·A Kacker, M Taskin
May 20, 1998·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·N KamikaidouM Sugimura
Aug 16, 2001·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·N G NikitakisJ J Sauk
May 11, 2002·Annals of Diagnostic Pathology·Alessandra F NascimentoChristopher D M Fletcher
Oct 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Julie C Fanburg-SmithEsther L B Childers
Oct 9, 2004·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Mary A FurlongEsther L B Childers
Oct 7, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Joshua WeaverBrian P Rubin
Oct 10, 2009·Virchows Archiv : an International Journal of Pathology·Jan LacoAles Ryska
Mar 31, 2011·Annals of Diagnostic Pathology·Esther ManorLipa Bodner
Sep 3, 2013·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Young Bin KimSeung O Ko
Oct 17, 2014·Head and Neck Pathology·Sean K LauLester D R Thompson
Aug 11, 2016·The American Journal of Surgical Pathology·Michael R ClayMark A Edgar
Sep 8, 2016·Journal of Oral and Maxillofacial Pathology : JOMFP·Fatemeh NiliArghavan Etebarian

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Citations

Feb 7, 2020·Medicine·Keiichi OhtaKazuo Sano
Mar 20, 2020·Journal of Oral and Maxillofacial Pathology : JOMFP·Nivedita KaoreyJyoti Bhavthankar
Jan 18, 2020·Head and Neck Pathology·Wonwoo Shon, Steven D Billings
Feb 20, 2021·Oral Oncology·John Lennon Silva CunhaRicardo Luiz Cavalcanti de Albuquerque-Júnior
Feb 10, 2021·Advances in Anatomic Pathology·Alessandro FranchiAlfio Ferlito
Dec 28, 2021·Histopathology·Khin Thway

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