Lipopeptide Paenipeptin Analogues Potentiate Clarithromycin and Rifampin against Carbapenem-Resistant Pathogens

Antimicrobial Agents and Chemotherapy
Sun Hee Moon, En Huang

Abstract

Two paenipeptin analogues at 4 μg/ml potentiated clarithromycin and rifampin against carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae strains. The combined treatment significantly increased their antibacterial efficacy in a microbiological medium and in human serum in vitro at therapeutically relevant concentrations. Moreover, these two paenipeptin analogues showed low cytotoxicity against a human kidney cell line. Therefore, combination therapy with paenipeptins may be an option for the treatment of antibiotic-resistant bacterial infections.

Citations

May 30, 2020·Organic & Biomolecular Chemistry·Juliana T W TongMargaret A Brimble
Jul 25, 2019·Frontiers in Cellular and Infection Microbiology·Kristin R BakerLuca Guardabassi

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