Lipopeptidomimetics derived from teixobactin have potent antibacterial activity against Staphylococcus aureus

Chemical Communications : Chem Comm
Georgina C GirtAndrew G Jamieson

Abstract

A series of lipopeptidomimetics derived from teixobactin have been prepared that probe the role of residues (1-6) as a membrane anchor and the function of enduracididine. The most active compounds, with a farnesyl tail and End10 to Lys10 or Orn10 substitution have potent activity (MIC 8 μg mL-1) against S. aureus. These results pave the way for the synthesis of simple, cost-effective yet potent lipopeptidomimetic antimicrobials.

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Citations

Jan 15, 2019·Organic & Biomolecular Chemistry·Bowen GaoZhengshuang Xu
Sep 14, 2018·Chemical Science·Po-Chao WenEmad Tajkhorshid
Oct 1, 2018·Journal of Industrial Microbiology & Biotechnology·Marc G Chevrette, Cameron R Currie
Dec 4, 2019·Annals of the New York Academy of Sciences·John A KarasTony Velkov
Aug 28, 2020·Frontiers in Chemistry·Victor V YimMargaret A Brimble
Feb 5, 2020·Current Research in Structural Biology·Kemin TanAndrzej Joachimiak
Jun 11, 2020·Journal of Medicinal Chemistry·Vidya B GunjalD Srinivasa Reddy

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Methods Mentioned

BETA
NMR

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