Lipophagy in atherosclerosis.

Clinica Chimica Acta; International Journal of Clinical Chemistry
Qing LiuHong-Feng Gu

Abstract

Atherosclerosis results from the excessive accumulation of lipids within the arterial wall. Lipophagy, referred to as the autophagic degradation of lipids, is a critical mechanism that regulates lipid metabolism in numerous cell types. The contribution of lipophagy to intracellular lipid turnover makes it a major player in the development and progression of atherosclerosis. This review addresses recent advances in lipid metabolism via lipophagy. The relationship between lipophagy and atherosclerosis is discussed focusing on the roles of lipophagy in vascular endothelial cell injury, vascular smooth muscle cells phenoypic shift, and macrophage lipid accumulation. A further understanding of lipophagy in these processes may provide promising new therapeutic options for atherosclerotic diseases.

References

May 23, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·O Traub, B C Berk
Jan 14, 1999·The New England Journal of Medicine·R Ross
Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
Feb 19, 2000·Current Opinion in Lipidology·C M Shanahan, P L Weissberg
Sep 23, 2000·Nature·A J Lusis
Nov 14, 2000·Circulation Research·H Cai, D G Harrison
Oct 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·James X RongEdward A Fisher
Sep 9, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Nader EldikaGuha Krishnaswamy
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson
Nov 17, 2007·Genes & Development·Noboru Mizushima
Nov 28, 2007·Annual Review of Pathology·Mondira Kundu, Craig B Thompson
Apr 3, 2009·Nature·Rajat SinghMark J Czaja
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Aug 2, 2011·Annual Review of Cell and Developmental Biology·Noboru MizushimaYoshinori Ohsumi
Oct 15, 2011·Nature Reviews. Immunology·Peter J Murray, Thomas A Wynn
Nov 9, 2011·Nature Medicine·Christian Weber, Heidi Noels
Mar 13, 2012·Cardiovascular Research·Delphine Gomez, Gary K Owens
Apr 21, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Enpeng Zhao, Mark J Czaja
Apr 27, 2012·International Journal of Cell Biology·Rajat Singh, Ana Maria Cuervo
May 19, 2012·Cell Death and Differentiation·K Liu, M J Czaja
Jun 14, 2012·Science Signaling·Agnes Roczniak-FergusonShawn M Ferguson
Apr 23, 2013·Nature Cell Biology·Carmine SettembreAndrea Ballabio
Jun 4, 2013·Free Radical Biology & Medicine·Traci MarinJohn Y-J Shyy
Sep 3, 2013·Nature Reviews. Immunology·Kathryn J MooreEdward A Fisher
Nov 22, 2013·Molecular Biology of the Cell·Tim van ZutphenSepp D Kohlwein
Oct 17, 2014·Immunological Reviews·Sophie ColinBart Staels
Nov 11, 2014·Nature·Sunmi SeokJongsook Kim Kemper
Nov 11, 2014·Nature·Jae Man LeeDavid D Moore
Jan 31, 2015·Circulation Research·Damián GaticaDaniel J Klionsky
Feb 6, 2015·The Journal of Clinical Investigation·Young Chul Kim, Kun-Liang Guan
May 9, 2015·The Journal of Physiology·Gang WangQingbo Xu
May 12, 2015·Nature Cell Biology·Susmita Kaushik, Ana Maria Cuervo

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Citations

Jun 16, 2021·Carbohydrate Polymers·Jiarui ZhaoShuliang Song

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