Lipophilic Statin Versus Rosuvastatin (Hydrophilic) Treatment for Heart Failure: a Meta-Analysis and Adjusted Indirect Comparison of Randomised Trials

Cardiovascular Drugs and Therapy
Kwadwo Osei BonsuAmudha Kadirvelu

Abstract

This study aims to compare lipophilic and hydrophilic statin therapy on clinical outcomes of heart failure (HF) using a systematic review and an adjusted indirect comparison meta-analysis. Outcomes were all-cause mortality, cardiovascular mortality, cardiovascular hospitalization and hospitalization for worsening HF. We conducted a search of PubMed, EMBASE and Cochrane databases until 31st December 2014 for randomized control trials (RCTs) in HF evaluating statins versus placebo. Identified RCTs and their respective abstracted information were grouped according to statin type evaluated and analyzed separately. Outcomes were initially pooled with the Peto's one-step method, producing odd ratios (OR) and 95 % confidence intervals (CI) for each statin type. Using these pooled estimates, we performed adjusted indirect comparisons of lipophilic versus hydrophilic statin for each outcome. Thirteen studies involving 10,966 patients were identified and analyzed. Lipophilic statins were superior to hydrophilic rosuvastatin regarding all-cause mortality (OR 0 · 50; 95 % CI, 0 · 11-0 · 89; p = 0 · 01), cardiovascular mortality (OR 0 · 61; 0 · 25-0 · 97; p = 0 · 009), and hospitalization for worsening HF (OR 0 · 52; 0 · 21-0 · 83; p = 0 · ...Continue Reading

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Citations

Jan 19, 2018·Journal of Cardiovascular Pharmacology and Therapeutics·Fadia MayyasKhalid Ibrahim
Apr 4, 2017·Journal of the American Heart Association·Kwadwo Osei BonsuAmudha Kadirvelu
Nov 13, 2019·Clinical Pharmacology and Therapeutics·Shih-Wei WangChien-Ning Hsu
Jan 3, 2020·Journal of Clinical Gastroenterology·Ryunosuke HakutaKazuhiko Koike
Nov 10, 2020·Archives of Endocrinology and Metabolism·Roberta de Pádua BorgesMarcello Casaccia Bertoluci
Feb 5, 2021·Journal of Cardiovascular Pharmacology·Chi ZhangJian Yang
Mar 12, 2021·Circulation Reports·Ryu ShuttaUNKNOWN Osaka Acute Coronary Insufficiency Study (OACIS) Investigators
Jun 8, 2021·Frontiers in Cardiovascular Medicine·Elisenda ClimentJuan Pedro-Botet
Feb 20, 2020·Cardiology·Setor K Kunutsor, Jari A Laukkanen
Apr 15, 2020·Cardiology·Tasnim ImranRishi J Desai

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