PMID: 8962119Dec 10, 1996Paper

Lipophosphoglycan from Leishmania suppresses agonist-induced interleukin 1 beta gene expression in human monocytes via a unique promoter sequence

Proceedings of the National Academy of Sciences of the United States of America
D E HatzigeorgiouJ L Ho

Abstract

Leishmania are parasites that survive within macrophages by mechanism(s) not entirely known. Depression of cellular immunity and diminished production of interleukin 1 beta (IL-1 beta) and tumor necrosis factor alpha are potential ways by which the parasite survives within macrophages. We examined the mechanism(s) by which lipophosphoglycan (LPG), a major glycolipid of Leishmania, perturbs cytokine gene expression. LPG treatment of THP-1 monocytes suppressed endotoxin induction of IL-1 beta steady-state mRNA by greater than 90%, while having no effect on the expression of a control gene. The addition of LPG 2 h before or 2 h after endotoxin challenge significantly suppressed steady-state IL-1 beta mRNA by 90% and 70%, respectively. LPG also inhibited tumor necrosis factor alpha and Staphylococcus induction of IL-1 beta gene expression. The inhibitory effect of LPG is agonist-specific because LPG did not suppress the induction of IL-1 beta mRNA by phorbol 12-myristate 13-acetate. A unique DNA sequence located within the -310 to -57 nucleotide region of the IL-1 beta promoter was found to mediate LPG's inhibitory activity. The requirement for the -310 to -57 promoter gene sequence for LPG's effect is demonstrated by the abrogatio...Continue Reading

References

Jan 1, 1992·European Journal of Immunology·M LuqmanK Bottomly
Jan 1, 1992·Annual Review of Microbiology·S J Turco, A Descoteaux
Feb 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·H W RogersR D Schreiber
May 1, 1990·Molecular and Biochemical Parasitology·M ElhayE Handman
Jun 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P GhazalL Hennighausen
Aug 1, 1988·Genes & Development·M Monk
Apr 1, 1988·Genes & Development·W R Folk
Aug 1, 1985·The Journal of Infectious Diseases·G D CrawfordC A Dinarello
Aug 1, 1980·International Journal of Cancer. Journal International Du Cancer·S TsuchiyaK Tada
Aug 12, 1994·Science·E Kopp, S Ghosh
May 1, 1994·Annals of Internal Medicine·C NatansonR L Danner
Oct 1, 1993·The Journal of Cell Biology·C Owen, D DeRosier
Jan 15, 1993·Cell·J H Kaplan
Jan 14, 1994·Science·C H OppermanM A Conkling

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Citations

Apr 6, 2004·International Journal for Parasitology·Tineke LauwaetAncy Leroy
Mar 21, 1998·International Journal for Parasitology·C Bogdan, M Röllinghoff
Aug 30, 2003·Molecular and Biochemical Parasitology·Ingeborg BeckerArmando Isibasi
Jul 11, 2002·Microbes and Infection·Albert Descoteaux, Salvatore J Turco
Nov 12, 2005·Parasitology·D J Gregory, M Olivier
Apr 16, 2005·Clinical Microbiology Reviews·Martin OlivierGeneviève Forget
Jul 20, 2010·Biochemistry. Biokhimii︠a︡·N M Novozhilova, N V Bovin
Dec 2, 2011·Journal of Tropical Medicine·Marina Tiemi ShioMartin Olivier
Oct 27, 2004·Bioscience, Biotechnology, and Biochemistry·Mariko Miyasato, Katsumi Ajisaka
Apr 24, 2012·Journal of Parasitology Research·Luis H FrancoDario S Zamboni
Dec 3, 2015·PLoS Neglected Tropical Diseases·Michelle A FavilaMary Ann McDowell
Jun 27, 2015·PLoS Neglected Tropical Diseases·Marina Tiemi ShioMartin Olivier
Aug 1, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R T GazzinelliJ S Silva
Jan 31, 2018·Frontiers in Microbiology·Sandra M MuxelLucile M Floeter-Winter
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M A CamposR T Gazzinelli
Mar 14, 2002·Experimental and Molecular Pathology·Anna C Cunningham
Nov 26, 1999·Biochimica Et Biophysica Acta·A Descoteaux, S J Turco

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