Lipopolysaccharide-activated dendritic cells: "exhausted" or alert and waiting?

The Journal of Immunology : Official Journal of the American Association of Immunologists
K AbdiPolly Matzinger

Abstract

LPS-activated dendritic cells (DCs) are thought to follow a set program in which they secrete inflammatory cytokines (such as IL-12) and then become refractory to further stimulation (i.e., "exhausted"). In this study, we show that mouse DCs do indeed lose their responsiveness to LPS, but nevertheless remain perfectly capable of making inflammatory cytokines in response to signals from activated T cells and to CD40-ligand and soluble T cell-derived signals. Furthermore, far from being rigidly programmed by the original activating stimulus, the DCs retained sufficient plasticity to respond differentially to interactions with Th0, Th1, Th2, and Th17 T cells. These data suggest that LPS activation does not exhaust DCs but rather primes them for subsequent signals from T cells.

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Citations

Jan 22, 2013·Annual Review of Immunology·Gianna Elena Hammer, Averil Ma
Apr 8, 2015·Molecular Medicine Reports·Ying Li, Juanjuan Ding
Jun 18, 2015·Frontiers in Immunology·Jashodeep DattaBrian J Czerniecki
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Aug 5, 2017·PloS One·Kaveh AbdiNevil J Singh
Oct 14, 2018·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kaveh AbdiRajat Varma
Feb 7, 2019·PLoS Pathogens·Yidan WangPablo Penaloza-MacMaster
Jun 17, 2014·Nature·Alban BessedePaolo Puccetti
Aug 3, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·César A TerrazasAbhay R Satoskar
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Dec 12, 2019·Frontiers in Immunology·Laura Stentoft CarstensenMorten Hansen
Feb 14, 2021·International Journal of Molecular Sciences·Denise van UdenRudi W Hendriks

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