Lipopolysaccharide and lipopolysaccharide-binding protein levels and their relationship to early metabolic improvement after bariatric surgery

Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery
Mercedes Clemente-PostigoFrancisco J Tinahones

Abstract

Bariatric surgery usually results in metabolic improvements within a few days from intervention, but the underlying mechanism is not completely understood and may vary depending on the bariatric procedure. Lipopolysaccharides (LPS) from gut microbiota have been proposed as a triggering factor for the inflammatory state in obesity. Roux-en-Y Gastric Bypass (RYGB) leads to a LPS decrease in the medium-term. To analyze LPS and LPS-binding protein (LBP) in normoglycemic (NG) and diabetic morbidly obese patients in the short-term after 2 different bariatric surgery procedures. University Hospital, Spain. Fifty morbidly obese patients underwent bariatric surgery: 24 with sleeve gastrectomy (SG) and 26 with biliopancreatic diversion (BPD). Patients were classified according to their glycemic status as NG or prediabetic/diabetic. LPS and LBP levels and biochemical and anthropometric variables were determined before and at days 15 and 90 after surgery. A significant LPS reduction was seen only in the prediabetic/diabetic patients at 90 days after SG. LBP levels rose at 15 days after BPD but at 90 days returned to baseline in both NG and prediabetic/diabetic patients. At 90 days after SG, LBP levels significantly decreased compared to ba...Continue Reading

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Citations

Oct 2, 2015·European Eating Disorders Review : the Journal of the Eating Disorders Association·Christine M PeatIan M Carroll
Nov 14, 2018·American Journal of Physiology. Endocrinology and Metabolism·Mercedes Clemente-PostigoFrancisco J Tinahones
Apr 27, 2019·Seminars in Immunopathology·Jean DebédatKarine Clément
Jan 4, 2020·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Sarah M RusselAntonio Gangemi
Apr 7, 2020·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Elisa Morales-MarroquinSarah E Messiah
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Oct 15, 2019·Frontiers in Endocrinology·Isabel Cornejo-ParejaFrancisco J Tinahones
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May 2, 2021·Clinical and Translational Medicine·Cristina Vals-DelgadoJose Lopez-Miranda
Jul 6, 2021·Frontiers in Endocrinology·Gracia M Martin-NuñezFrancisco J Tinahones

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