Lipopolysaccharide as shield and receptor for R-pyocin-mediated killing in Pseudomonas aeruginosa.

Journal of Bacteriology
Thilo KöhlerChristian van Delden

Abstract

Pseudomonas aeruginosa produces three different types of bacteriocins: the soluble S-pyocins and the bacteriophage-like F- and R-pyocins. R-pyocins kill susceptible bacteria of the same or closely related species with high efficiency. Five different types of R-pyocins (R1- to R5-pyocins) have been described based on their killing spectra and tail fiber protein sequences. We analyzed the distribution of R-pyocin genes in a collection of clinical P. aeruginosa isolates. We found similar percentages of isolates not containing R-pyocins (28%) and isolates containing genes encoding R1-pyocins (25%), R2-pyocins (17%), and R5-pyocins (29%). The R-pyocin-deficient isolates were susceptible to R1-, R2-, and R5-pyocins, while most R2- and R5- pyocin producers were resistant. Determination of the O serotypes revealed that the R-pyocin-susceptible isolates belonged to serotypes O1, O3, and O6, while the R-pyocin-resistant isolates were serotype O10, O11, and O12 isolates. We hypothesized that O-serotype-specific lipopolysaccharide (LPS) packaging densities may account for the distinct accessibilities of R-pyocins to their receptors at the cell surface. Using genetically defined LPS mutants, we showed that the l-Rha residue and two distinct...Continue Reading

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Apr 1, 2009·Proceedings of the National Academy of Sciences of the United States of America·Thilo KöhlerChristian van Delden

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Citations

Feb 9, 2011·Nature Reviews. Genetics·Kevin R Foster
Mar 8, 2013·PLoS Pathogens·Maarten G K GhequireRené De Mot
Aug 28, 2015·Proceedings. Biological Sciences·Melanie GhoulAshleigh S Griffin
Jun 14, 2014·FEMS Microbiology Reviews·Maarten G K Ghequire, René De Mot
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Jul 12, 2011·Toxicon : Official Journal of the International Society on Toxinology·Haiyan MaAllan Cembella
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Aug 8, 2018·FEMS Microbiology Reviews·Jeella Z AcedoMarco J van Belkum
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Aug 17, 2018·Viruses·Sergey A ButhPetr G Leiman

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