Lipopolysaccharide-binding protein (LBP) and markers of acute-phase response in patients with multiple organ dysfunction syndrome (MODS) following open heart surgery

The Thoracic and Cardiovascular Surgeon
A SablotzkiE Czeslick

Abstract

Cardiopulmonary bypass (CPB) is associated with an immunological injury that may cause pathophysiological alterations in the form of a systemic inflammatory response syndrome (SIRS) or a multiple organ dysfunction syndrome (MODS). Previous studies on this issue have reported different changes of immunological parameters during and after CPB, but there are no reports about the lipopolysaccharide-binding protein (LBP) in relationship to other markers of inflammation in patients with MODS following cardiovascular surgery. In the present study, we investigated the acute-phase response of patients with MODS of infectious and non-infectious origin following open-heart-surgery. Plasma levels of procalcitonin (PCT), c-reactive protein (CRP), interleukin-6 (IL-6), and LBP were measured in the first four postoperative days in 12 adult male patients with the signs of SIRS and two or more organ dysfunctions after myocardial revascularization (MODS-group), and 12 patients without organ insufficiencies (SIRS-group). There were no significant differences regarding age, weight, height, preoperative NYHA-classification, preoperative LVEDP, or the number of anastomosis. Patients with MODS had a significantly longer operation time, duration of is...Continue Reading

Citations

Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
Aug 1, 2006·Surgical Infections·Steven C CunninghamLena M Napolitano
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Jun 17, 2008·Critical Care Medicine·Yasser SakrFrank Brunkhorst
Nov 20, 2003·Critical Care : the Official Journal of the Critical Care Forum·Miroslav PruchaJosef Hyanek
Sep 26, 2006·Critical Care : the Official Journal of the Critical Care Forum·D Shane O'MahonyGustavo Matute-Bello
Oct 14, 2006·Critical Care : the Official Journal of the Critical Care Forum·Christoph SponholzFrank Brunkhorst
Dec 11, 2003·Chest·Argyris S MichalopoulosSpyros D Mentzelopoulos
Feb 1, 2012·The Annals of Thoracic Surgery·Ruth HeyingMarie-Christine Seghaye
Aug 13, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Susan Garwood
Jun 27, 2006·The Annals of Thoracic Surgery·Axel FrankeAndreas Markewitz
May 31, 2006·The Journal of Thoracic and Cardiovascular Surgery·Martin WesterbergAnders Jeppsson
Sep 8, 2006·The Journal of Biological Chemistry·Kota V RamanaSatish K Srivastava
Oct 4, 2008·Clinical Chemistry·Tanja VollmerJens Dreier
Oct 6, 2006·Current Opinion in Anaesthesiology·Athena F Zuppa, Vinay M Nadkarni
Jun 12, 2020·Journal of Cardiothoracic Surgery·Yun-Wen PengJohn R Charpie
Feb 4, 2021·Environmental Science and Pollution Research International·Madhuri GroverLotfi Aleya

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