PMID: 7543076Jun 1, 1995Paper

Lipopolysaccharide-induced E-selectin expression requires continuous presence of LPS and is inhibited by bactericidal/permeability-increasing protein

Inflammation
K HuangR L Dedrick

Abstract

Endothelial cells stimulated by LPS express E-selectin, which plays an important role in mediating neutrophil adhesion during inflammation. E-selectin is induced within 1-2 h, peaks at 4-6 h, and gradually returns to basal level by 24 h. rBPI21, a recombinant N-terminal fragment of human bactericidal/permeability-increasing protein (BPI), inhibited LPS-induced E-selectin expression when added at the same time as, and up to 6 h after, LPS. Delayed administration of rBPI21 also affected LPS-mediated activation of the nuclear factor, NF-kappa B. Two to 4 h following LPS addition to endothelial cells, when NF-kappa B was already activated, addition of rBPI21 resulted in marked reduction of NF-kappa B detectable at 4 or 6 h. These results indicate that endothelial activation requires continuous presence of LPS, and rBPI21 acts to reverse LPS-mediated endothelial activation by interrupting the on-going LPS signal.

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Citations

Aug 8, 2002·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·Kazuyoshi Hanasawa
Sep 13, 2002·American Journal of Veterinary Research·Gabrielle LandoltKris T Kruse-Elliott
Sep 9, 1999·Radiology·L FengJ Pile-Spellman
Jan 6, 2005·Archives of Medical Research·Lucia Nikolaia López-BojórquezGustavo Reyes-Terán
Jun 22, 2006·Forensic Science International : Synergy·Michael Tsokos
Feb 19, 2008·Brazilian Dental Journal·José F Siqueira, Isabela N Rôças

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